STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SMB97877.1Diguanylate cyclase (GGDEF) domain-containing protein; InterPro IPR000644:IPR000160; COGs: COG2199 FOG: GGDEF domain; KEGG: mta:Moth_0521 diguanylate cyclase; SPTR: Diguanylate cyclase (GGDEF domain); SMART: CBS domain containing protein; GGDEF domain containing protein; PFAM: CBS domain containing protein; GGDEF domain containing protein; TIGRFAM: diguanylate cyclase. (297 aa)    
Predicted Functional Partners:
SMB97879.1
KEGG: mta:Moth_0522 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.960
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
 0.946
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
  
0.932
SMB89163.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterProIPR011895:IPR017896:IPR017900:IPR002880:IPR 019752:IPR019456:IPR011766; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: mta:Moth_0064 pyruvate:ferredoxin (flavodoxin) oxidoreductase; SPTR: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing p [...]
    
  0.906
SMB97029.1
PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein; InterProIPR000014:IPR000700:IPR000160:IPR013767:IPR 006674; COGs: COG2206 HD-GYP domain; KEGG: diguanylate cyclase and metal dependent phosphohydrolase; SPTR: Sensory box protein; SMART: GGDEF domain containing protein; PAS domain containing protein; PFAM: GGDEF domain containing protein; PAS fold domain protein; metal-dependent phosphohydrolase HD sub domain; TIGRFAM: diguanylate cyclase; PAS sensor protein.
 
0.895
SMB99786.1
PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein; InterProIPR013767:IPR000160:IPR006674:IPR000014:IPR 000700; COGs: COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain; KEGG: diguanylate cyclase and metal dependent phosphohydrolase; SPTR: Sensory box protein; SMART: GGDEF domain containing protein; PAS domain containing protein; PFAM: GGDEF domain containing protein; PAS fold domain protein; metal-dependent phosphohydrolase HD sub domain; TIGRFAM: diguanylate cyclase; PAS sensor protein.
 
0.895
SMB99788.1
HDIG domain-containing protein; InterProIPR018771:IPR003018:IPR006674:IPR006675:IPR 003607; COGs: COG2206 HD-GYP domain; KEGG: mta:Moth_2150 metal dependent phosphohydrolase; SPTR: Metal dependent phosphohydrolase; SMART: metal-dependent phosphohydrolase HD region; GAF domain protein; PFAM: Transcription regulator,histidine kinase sensor-like; GAF domain protein; metal-dependent phosphohydrolase HD sub domain; TIGRFAM: metal dependent phophohydrolase.
 
 0.892
SMB97023.1
HDIG domain-containing protein; InterProIPR006675:IPR018771:IPR003018:IPR006674:IPR 003607; COGs: COG2206 HD-GYP domain; KEGG: mta:Moth_2150 metal dependent phosphohydrolase; SPTR: Metal dependent phosphohydrolase; PFAM: Transcription regulator,histidine kinase sensor-like; GAF domain protein; metal-dependent phosphohydrolase HD sub domain; TIGRFAM: metal dependent phophohydrolase; SMART: metal-dependent phosphohydrolase HD region; GAF domain protein.
 
 0.882
SMB98191.1
HD domain-containing protein; InterPro IPR006674; COGs: COG2206 HD-GYP domain; KEGG: diguanylate cyclase and metal dependent phosphohydrolase; SPTR: HD-GYP domain; PFAM: metal-dependent phosphohydrolase HD sub domain.
  
 0.861
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.852
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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