STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SMB99043.1InterPro IPR002529; COGs: COG3971 2-keto-4-pentenoate hydratase; KEGG: mta:Moth_1777 4-oxalocrotonate decarboxylase; SPTR: 4-oxalocrotonate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; PRIAM: 2-oxopent-4-enoate hydratase. (257 aa)    
Predicted Functional Partners:
SMB99042.1
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
  
 0.994
SMB99041.1
4-hydroxy 2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 
 0.985
SMB99038.1
BFD-like [2Fe-2S] binding domain-containing protein; InterPro IPR017896:IPR017900:IPR007419; KEGG: mta:Moth_1774 4Fe-4S ferredoxin, iron-sulfur binding; SPTR: 4Fe-4S ferredoxin, iron-sulfur binding; PFAM: BFD domain protein [2Fe-2S]-binding domain protein.
 
     0.854
SMB99044.1
Molybdenum cofactor synthesis domain-containing protein; InterPro IPR001453; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; KEGG: mta:Moth_1778 molybdopterin binding domain-containing protein; SPTR: Molybdopterin binding domain; PFAM: molybdopterin binding domain.
 
     0.795
SMB99036.1
KEGG: mta:Moth_1773 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.784
SMB99045.1
InterPro IPR002638:IPR000056; KEGG: mta:Moth_1779 nicotinate-nucleotide pyrophosphorylase; SPTR: Nicotinate-nucleotide pyrophosphorylase (Carboxylating); PFAM: ribulose-phosphate 3-epimerase; Quinolinate phosphoribosyl transferase; COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase.
       0.670
SMC00064.1
COGs: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway); KEGG: mta:Moth_1492 5-carboxymethyl-2-hydroxymuconate delta-isomerase; SPTR: 5-carboxymethyl-2-hydroxymuconate delta-isomerase; InterPro IPR002529; PFAM: fumarylacetoacetate (FAA) hydrolase; PRIAM: Ureidoglycolate lyase.
  
 
 0.666
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.633
SMB90800.1
2-isopropylmalate synthase; InterPro IPR002034:IPR000891:IPR013709:IPR005675; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; KEGG: mta:Moth_2251 putative alpha-isopropylmalate/homocitrate synthase family transferase; SPTR: 2-isopropylmalate synthase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.633
SMB93646.1
HMGL-like; InterPro IPR000891:IPR002034; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; KEGG: dhd:Dhaf_2055 2-isopropylmalate synthase; SPTR: 2-isopropylmalate synthase; PFAM: pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.633
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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