STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMB99141.1Phosphoglycolate phosphatase; InterPro IPR006439:IPR005834:IPR005833; COGs: COG0546 phosphatase; KEGG: gym:GYMC10_1612 HAD-superfamily hydrolase, subfamily IA, variant 3; SPTR: HAD-superfamily hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1. (250 aa)    
Predicted Functional Partners:
moaA
Cyclic pyranopterin monophosphate synthase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
    0.779
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
  0.772
cinA
Competence/damage-inducible protein cinA; InterPro IPR008135:IPR001453:IPR008136; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; KEGG: mta:Moth_0735 competence/damage-inducible protein CinA; SPTR: Putative competence-damage inducible protein; PFAM: CinA domain protein; molybdopterin binding domain; TIGRFAM: competence/damage-inducible protein CinA.
    
 0.737
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
   
 
  0.705
SMB99732.1
Fe-S oxidoreductase/FAD/FMN-containing dehydrogenase; InterPro IPR006094:IPR004113:IPR004017:IPR016166; COGs: COG0247 Fe-S oxidoreductase; KEGG: FAD linked oxidase domain protein; SPTR: Cysteine-rich domain protein/FAD binding domain protein; PFAM: FAD linked oxidase domain protein; protein of unknown function DUF224 cysteine-rich region domain protein.
    
 0.688
SMC00073.1
Fe-S oxidoreductase; InterProIPR006094:IPR004113:IPR004017:IPR017896:IPR 016166; COGs: COG0247 Fe-S oxidoreductase; KEGG: FAD linked oxidase domain protein; SPTR: Heterodisulfide reductase, iron-sulfur subunit domain protein; PFAM: FAD linked oxidase domain protein; protein of unknown function DUF224 cysteine-rich region domain protein.
    
 0.688
SMB99140.1
KEGG: mta:Moth_1864 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.658
ribBA
3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.630
SMB89163.1
Pyruvate-ferredoxin/flavodoxin oxidoreductase; InterProIPR011895:IPR017896:IPR017900:IPR002880:IPR 019752:IPR019456:IPR011766; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; KEGG: mta:Moth_0064 pyruvate:ferredoxin (flavodoxin) oxidoreductase; SPTR: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing p [...]
     
 0.622
SMB99426.1
Beta-phosphoglucomutase; InterPro IPR005834:IPR010972:IPR010976:IPR006402; COGs: COG0637 phosphatase/phosphohexomutase; KEGG: tpd:Teth39_1517 beta-phosphoglucomutase; SPTR: Beta-phosphoglucomutase; PFAM: Haloacid dehalogenase domain protein hydrolase; TIGRFAM: beta-phosphoglucomutase; beta-phosphoglucomutase family hydrolase; HAD-superfamily hydrolase, subfamily IA, variant 3.
 
 
0.593
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.