STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMC00140.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; InterPro IPR006218:IPR006268; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; KEGG: mta:Moth_2412 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; SPTR: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (366 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
 
 0.984
pheA
Prephenate dehydratase; InterPro IPR001086:IPR002912:IPR018528; COGs: COG0077 Prephenate dehydratase; KEGG: mta:Moth_1334 prephenate dehydratase; SPTR: Prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydratase.
 
 
 0.959
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.800
SMB98332.1
Prephenate dehydrogenase; InterPro IPR003099:IPR002912; COGs: COG0287 Prephenate dehydrogenase; KEGG: mta:Moth_1333 prephenate dehydrogenase; SPTR: Prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydrogenase.
 
 0.774
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 
 0.707
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
  
 0.668
SMB98354.1
Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
 
  
 0.659
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
  
 0.613
SMC00132.1
Lipid II:glycine glycyltransferase (Peptidoglycan interpeptide bridge formation enzyme); InterPro IPR003447; COGs: COG2348 Uncharacterized protein involved in methicillin resistance; KEGG: mta:Moth_2408 methicillin resistance protein; SPTR: Methicillin resistance protein; PFAM: Methicillin resistance protein.
       0.573
SMB98349.1
Anthranilate synthase component 2; InterProIPR006221:IPR000991:IPR006220:IPR011702:IPR 001317:IPR017926; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; KEGG: mta:Moth_1341 anthranilate synthase, component II; SPTR: Anthranilate synthase, component II; PFAM: glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase.
  
 
 0.551
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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