node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFH55384.1 | fhs | SAMN05192551_101488 | SAMN05192551_102142 | Phosphoribosylformylglycinamidine synthase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.982 |
SFH55384.1 | glyA | SAMN05192551_101488 | SAMN05192551_10192 | Phosphoribosylformylglycinamidine synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
SFH55384.1 | purC | SAMN05192551_101488 | SAMN05192551_102328 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.999 |
SFH55384.1 | purD | SAMN05192551_101488 | SAMN05192551_102333 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.999 |
SFH55384.1 | purE | SAMN05192551_101488 | SAMN05192551_102327 | Phosphoribosylformylglycinamidine synthase. | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.999 |
SFH55384.1 | purF | SAMN05192551_101488 | SAMN05192551_102329 | Phosphoribosylformylglycinamidine synthase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
SFH55384.1 | purH | SAMN05192551_101488 | SAMN05192551_102332 | Phosphoribosylformylglycinamidine synthase. | IMP cyclohydrolase. | 0.999 |
SFH55384.1 | purK | SAMN05192551_101488 | SAMN05192551_102326 | Phosphoribosylformylglycinamidine synthase. | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.999 |
SFH55384.1 | purM | SAMN05192551_101488 | SAMN05192551_102330 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylformylglycinamidine cyclo-ligase. | 0.999 |
SFH55384.1 | purN | SAMN05192551_101488 | SAMN05192551_102331 | Phosphoribosylformylglycinamidine synthase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
fhs | SFH55384.1 | SAMN05192551_102142 | SAMN05192551_101488 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine synthase. | 0.982 |
fhs | glyA | SAMN05192551_102142 | SAMN05192551_10192 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.983 |
fhs | purC | SAMN05192551_102142 | SAMN05192551_102328 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.760 |
fhs | purD | SAMN05192551_102142 | SAMN05192551_102333 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.828 |
fhs | purE | SAMN05192551_102142 | SAMN05192551_102327 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.646 |
fhs | purF | SAMN05192551_102142 | SAMN05192551_102329 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.816 |
fhs | purH | SAMN05192551_102142 | SAMN05192551_102332 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | IMP cyclohydrolase. | 0.979 |
fhs | purK | SAMN05192551_102142 | SAMN05192551_102326 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.467 |
fhs | purM | SAMN05192551_102142 | SAMN05192551_102330 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine cyclo-ligase. | 0.494 |
fhs | purN | SAMN05192551_102142 | SAMN05192551_102331 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.963 |