node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFH53597.1 | SFH59083.1 | SAMN05192551_101411 | SAMN05192551_101679 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dihydrolipoamide dehydrogenase. | 0.835 |
SFH53597.1 | SFH68872.1 | SAMN05192551_101411 | SAMN05192551_102177 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dihydrolipoamide dehydrogenase. | 0.835 |
SFH53597.1 | SFH89468.1 | SAMN05192551_101411 | SAMN05192551_10482 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dihydrolipoamide dehydrogenase. | 0.835 |
SFH53597.1 | SFI03618.1 | SAMN05192551_101411 | SAMN05192551_105222 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine dehydrogenase subunit 2. | 0.860 |
SFH53597.1 | gcvH | SAMN05192551_101411 | SAMN05192551_10485 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.946 |
SFH53597.1 | gcvPA | SAMN05192551_101411 | SAMN05192551_10484 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.803 |
SFH53597.1 | gcvPB | SAMN05192551_101411 | SAMN05192551_10483 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.860 |
SFH53597.1 | gcvT | SAMN05192551_101411 | SAMN05192551_10486 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.977 |
SFH53597.1 | glyA | SAMN05192551_101411 | SAMN05192551_10192 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |
SFH55384.1 | SFH59083.1 | SAMN05192551_101488 | SAMN05192551_101679 | Phosphoribosylformylglycinamidine synthase. | Dihydrolipoamide dehydrogenase. | 0.460 |
SFH55384.1 | SFH68872.1 | SAMN05192551_101488 | SAMN05192551_102177 | Phosphoribosylformylglycinamidine synthase. | Dihydrolipoamide dehydrogenase. | 0.460 |
SFH55384.1 | SFH89468.1 | SAMN05192551_101488 | SAMN05192551_10482 | Phosphoribosylformylglycinamidine synthase. | Dihydrolipoamide dehydrogenase. | 0.460 |
SFH55384.1 | SFI03618.1 | SAMN05192551_101488 | SAMN05192551_105222 | Phosphoribosylformylglycinamidine synthase. | Glycine dehydrogenase subunit 2. | 0.813 |
SFH55384.1 | gcvH | SAMN05192551_101488 | SAMN05192551_10485 | Phosphoribosylformylglycinamidine synthase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.762 |
SFH55384.1 | gcvPA | SAMN05192551_101488 | SAMN05192551_10484 | Phosphoribosylformylglycinamidine synthase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.742 |
SFH55384.1 | gcvPB | SAMN05192551_101488 | SAMN05192551_10483 | Phosphoribosylformylglycinamidine synthase. | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.813 |
SFH55384.1 | gcvT | SAMN05192551_101488 | SAMN05192551_10486 | Phosphoribosylformylglycinamidine synthase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.736 |
SFH55384.1 | glyA | SAMN05192551_101488 | SAMN05192551_10192 | Phosphoribosylformylglycinamidine synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
SFH59083.1 | SFH53597.1 | SAMN05192551_101679 | SAMN05192551_101411 | Dihydrolipoamide dehydrogenase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.835 |
SFH59083.1 | SFH55384.1 | SAMN05192551_101679 | SAMN05192551_101488 | Dihydrolipoamide dehydrogenase. | Phosphoribosylformylglycinamidine synthase. | 0.460 |