Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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[Homology]
Score
lpdDihydrolipoamide dehydrogenase (PdhD). (458 aa)    
Predicted Functional Partners:
acoB
Pyruvate dehydrogenase E1 component subunit beta (PdhB).
  
 0.999
aceF
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (PdhC).
 
 0.999
acoA
Pyruvate dehydrogenase E1 component subunit alpha (PdhA); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 
 0.995
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.938
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.920
CCP87989.1
Pyruvate dehydrogenase E1 component (AcoA/PdhA, alpha subunit), putative fragment.
  
 
 0.833
pykF
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
  
 0.762
dnaK
RecName: Full=Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.693
scfA
Malic enzyme.
  
 
 0.686
pqpB
Probable membrane-associated phospholipid phosphatase.
  
  
 0.684
Your Current Organism:
Phytoplasma solani
NCBI taxonomy Id: 69896
Other names: C. Phytoplasma solani, Candidatus Phytoplasma solani, Stolbur phytoplasma, strain STOL11
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