| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCP88129.1 | CCP88282.1 | S284_01920 | S284_03450 | Conserved hypothetical protein, phage-related protein. | Conserved hypothetical protein. | 0.520 |
| CCP88282.1 | CCP88129.1 | S284_03450 | S284_01920 | Conserved hypothetical protein. | Conserved hypothetical protein, phage-related protein. | 0.520 |
| CCP88282.1 | folA | S284_03450 | S284_03470 | Conserved hypothetical protein. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.550 |
| CCP88282.1 | norM4 | S284_03450 | S284_03850 | Conserved hypothetical protein. | Na+-driven multidrug efflux pump. | 0.508 |
| CCP88282.1 | plsC | S284_03450 | S284_03460 | Conserved hypothetical protein. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.632 |
| CCP88282.1 | thiJ | S284_03450 | S284_03960 | Conserved hypothetical protein. | 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme. | 0.416 |
| CCP88282.1 | thyA | S284_03450 | S284_03480 | Conserved hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.551 |
| folA | CCP88282.1 | S284_03470 | S284_03450 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Conserved hypothetical protein. | 0.550 |
| folA | plsC | S284_03470 | S284_03460 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.867 |
| folA | thyA | S284_03470 | S284_03480 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.994 |
| norM4 | CCP88282.1 | S284_03850 | S284_03450 | Na+-driven multidrug efflux pump. | Conserved hypothetical protein. | 0.508 |
| plsC | CCP88282.1 | S284_03460 | S284_03450 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | Conserved hypothetical protein. | 0.632 |
| plsC | folA | S284_03460 | S284_03470 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.867 |
| plsC | thyA | S284_03460 | S284_03480 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.847 |
| thiJ | CCP88282.1 | S284_03960 | S284_03450 | 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme. | Conserved hypothetical protein. | 0.416 |
| thyA | CCP88282.1 | S284_03480 | S284_03450 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Conserved hypothetical protein. | 0.551 |
| thyA | folA | S284_03480 | S284_03470 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.994 |
| thyA | plsC | S284_03480 | S284_03460 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.847 |