| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCP88282.1 | folA | S284_03450 | S284_03470 | Conserved hypothetical protein. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.550 |
| CCP88282.1 | plsC | S284_03450 | S284_03460 | Conserved hypothetical protein. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.632 |
| CCP88282.1 | thyA | S284_03450 | S284_03480 | Conserved hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.551 |
| cdsA | plsC | S284_03290 | S284_03460 | CDP-diglyceride synthetase, partial CDS; Belongs to the CDS family. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.930 |
| folA | CCP88282.1 | S284_03470 | S284_03450 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Conserved hypothetical protein. | 0.550 |
| folA | plsC | S284_03470 | S284_03460 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.867 |
| folA | thyA | S284_03470 | S284_03480 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.994 |
| gpsA | nadE | S284_04380 | S284_02970 | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | NAD+ synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.459 |
| gpsA | plsC | S284_04380 | S284_03460 | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.863 |
| gpsA | plsY | S284_04380 | S284_04460 | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. | 0.938 |
| gpsA | pykF | S284_04380 | S284_00050 | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.419 |
| mdlA | mdlB | S284_02490 | S284_02480 | Multidrug resistance ABC transporter ATP-binding and permease protein. | ABC-type multidrug/protein/lipid transport system, ATPase component. | 0.986 |
| mdlA | plsC | S284_02490 | S284_03460 | Multidrug resistance ABC transporter ATP-binding and permease protein. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.564 |
| mdlA | pykF | S284_02490 | S284_00050 | Multidrug resistance ABC transporter ATP-binding and permease protein. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.421 |
| mdlB | mdlA | S284_02480 | S284_02490 | ABC-type multidrug/protein/lipid transport system, ATPase component. | Multidrug resistance ABC transporter ATP-binding and permease protein. | 0.986 |
| mdlB | plsC | S284_02480 | S284_03460 | ABC-type multidrug/protein/lipid transport system, ATPase component. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.564 |
| mdlB | pykF | S284_02480 | S284_00050 | ABC-type multidrug/protein/lipid transport system, ATPase component. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.421 |
| nadE | gpsA | S284_02970 | S284_04380 | NAD+ synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.459 |
| nadE | plsC | S284_02970 | S284_03460 | NAD+ synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.628 |
| nadE | pykF | S284_02970 | S284_00050 | NAD+ synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.587 |