Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobB-2Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (242 aa)    
Predicted Functional Partners:
EFD94668.1
Hypothetical protein; Identified by glimmer; putative.
   
 0.917
deoD
Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107.
    
 0.907
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
    
 0.888
nadK
NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.867
nadE
NAD+ synthase; Identified by match to protein family HMM PF02540; match to protein family HMM PF06508; match to protein family HMM TIGR00552; Belongs to the NAD synthetase family.
    
 0.857
EFD93642.1
Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; Identified by match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.828
recQ
ATP-dependent DNA helicase RecQ; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF00570; match to protein family HMM PF09382; match to protein family HMM TIGR00614; match to protein family HMM TIGR01389.
  
   0.785
EFD94761.1
Hypothetical protein; Identified by glimmer; putative.
   
 0.784
atpD
ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
    
 0.778
EFD93807.1
Histidine triad domain protein; Identified by match to protein family HMM PF01230.
  
 
  0.768
Your Current Organism:
Megasphaera genomosp.
NCBI taxonomy Id: 699218
Other names: M. genomosp. type_1 str. 28L, Megasphaera genomosp. type_1 str. 28L
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