node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADC91246.1 | ADC91794.1 | HMPREF0868_1013 | HMPREF0868_0621 | DNA polymerase III, delta' subunit. | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | 0.994 |
ADC91246.1 | dnaN | HMPREF0868_1013 | HMPREF0868_0092 | DNA polymerase III, delta' subunit. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.998 |
ADC91246.1 | dnaX | HMPREF0868_1013 | HMPREF0868_1019 | DNA polymerase III, delta' subunit. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.996 |
ADC91246.1 | holA | HMPREF0868_1013 | HMPREF0868_0895 | DNA polymerase III, delta' subunit. | DNA polymerase III, delta subunit; Identified by match to protein family HMM PF06144; match to protein family HMM TIGR01128. | 0.994 |
ADC91246.1 | polA | HMPREF0868_1013 | HMPREF0868_0853 | DNA polymerase III, delta' subunit. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.941 |
ADC91246.1 | polC | HMPREF0868_1013 | HMPREF0868_0936 | DNA polymerase III, delta' subunit. | DNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.912 |
ADC91246.1 | topA | HMPREF0868_1013 | HMPREF0868_0860 | DNA polymerase III, delta' subunit. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.590 |
ADC91576.1 | ADC91794.1 | HMPREF0868_1385 | HMPREF0868_0621 | Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | 0.938 |
ADC91576.1 | dnaN | HMPREF0868_1385 | HMPREF0868_0092 | Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.456 |
ADC91576.1 | dnaX | HMPREF0868_1385 | HMPREF0868_1019 | Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.945 |
ADC91576.1 | polA | HMPREF0868_1385 | HMPREF0868_0853 | Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.741 |
ADC91576.1 | topA | HMPREF0868_1385 | HMPREF0868_0860 | Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.935 |
ADC91751.1 | ADC91794.1 | HMPREF0868_0620 | HMPREF0868_0621 | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Identified by match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | 0.756 |
ADC91751.1 | uvrB | HMPREF0868_0620 | HMPREF0868_0619 | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Identified by match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.625 |
ADC91794.1 | ADC91246.1 | HMPREF0868_0621 | HMPREF0868_1013 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase III, delta' subunit. | 0.994 |
ADC91794.1 | ADC91576.1 | HMPREF0868_0621 | HMPREF0868_1385 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. | 0.938 |
ADC91794.1 | ADC91751.1 | HMPREF0868_0621 | HMPREF0868_0620 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Identified by match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. | 0.756 |
ADC91794.1 | dnaN | HMPREF0868_0621 | HMPREF0868_0092 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.994 |
ADC91794.1 | dnaX | HMPREF0868_0621 | HMPREF0868_1019 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.995 |
ADC91794.1 | holA | HMPREF0868_0621 | HMPREF0868_0895 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase III, delta subunit; Identified by match to protein family HMM PF06144; match to protein family HMM TIGR01128. | 0.994 |