STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rdgBNon-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (199 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
 
 
 0.953
ADC91301.1
Inosine 5-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM PF00571.
  
 0.941
guaA-2
GMP synthase (glutamine-hydrolyzing) domain protein; Identified by match to protein family HMM PF00958; match to protein family HMM PF06508; match to protein family HMM TIGR00884.
 
 
 0.930
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 0.914
ADC91143.1
Hydrolase, NUDIX family; Identified by match to protein family HMM PF00293.
  
 
 0.908
hpt
Hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.905
ADC90874.1
Identified by match to protein family HMM PF01189.
 
  
 0.852
ADC91523.1
Identified by match to protein family HMM PF02588.
 
    0.820
argS
arginine--tRNA ligase; Identified by match to protein family HMM PF00750; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM TIGR00456.
  
    0.806
ADC91551.1
Hypothetical protein.
       0.778
Your Current Organism:
Mageeibacillus indolicus
NCBI taxonomy Id: 699246
Other names: Clostridiales genomosp. BVAB3 str. UPII9-5, M. indolicus UPII9-5, Mageeibacillus indolicus UPII9-5
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.