node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADC90681.1 | ADC91363.1 | HMPREF0868_1309 | HMPREF0868_0618 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | 0.652 |
ADC90681.1 | clpP | HMPREF0868_1309 | HMPREF0868_1302 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.911 |
ADC90681.1 | dnaJ | HMPREF0868_1309 | HMPREF0868_0780 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.788 |
ADC90681.1 | dnaK | HMPREF0868_1309 | HMPREF0868_0779 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.905 |
ADC90681.1 | groL | HMPREF0868_1309 | HMPREF0868_0834 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.585 |
ADC90681.1 | groS | HMPREF0868_1309 | HMPREF0868_0833 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.610 |
ADC90681.1 | grpE | HMPREF0868_1309 | HMPREF0868_0778 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.700 |
ADC90681.1 | tig | HMPREF0868_1309 | HMPREF0868_1303 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.432 |
ADC91363.1 | ADC90681.1 | HMPREF0868_0618 | HMPREF0868_1309 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.652 |
ADC91363.1 | ADC91413.1 | HMPREF0868_0618 | HMPREF0868_0472 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.652 |
ADC91363.1 | atpA | HMPREF0868_0618 | HMPREF0868_1121 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | 0.624 |
ADC91363.1 | clpP | HMPREF0868_0618 | HMPREF0868_1302 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.479 |
ADC91363.1 | dnaJ | HMPREF0868_0618 | HMPREF0868_0780 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.964 |
ADC91363.1 | dnaK | HMPREF0868_0618 | HMPREF0868_0779 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.995 |
ADC91363.1 | groL | HMPREF0868_0618 | HMPREF0868_0834 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.899 |
ADC91363.1 | groS | HMPREF0868_0618 | HMPREF0868_0833 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.802 |
ADC91363.1 | grpE | HMPREF0868_0618 | HMPREF0868_0778 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.784 |
ADC91413.1 | ADC91363.1 | HMPREF0868_0472 | HMPREF0868_0618 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Identified by match to protein family HMM PF00183; match to protein family HMM PF02518. | 0.652 |
ADC91413.1 | clpP | HMPREF0868_0472 | HMPREF0868_1302 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.883 |
ADC91413.1 | dnaJ | HMPREF0868_0472 | HMPREF0868_0780 | ATPase family associated with various cellular activities (AAA); Identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.788 |