ADC91175.1 protein (Mageeibacillus indolicus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

ADC91175.1

Hypothetical protein. (290 aa)

Predicted Functional Partners:

pepT

0.550

ADC91249.1

0.425

serS

0.425

Your Current Organism:

Mageeibacillus indolicus

NCBI taxonomy Id: 699246
Other names: Clostridiales genomosp. BVAB3 str. UPII9-5, M. indolicus UPII9-5, Mageeibacillus indolicus UPII9-5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADC91175.1	ADC91249.1	HMPREF0868_1256	HMPREF0868_1258	Hypothetical protein.	Identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797.	0.425
ADC91175.1	pepT	HMPREF0868_1256	HMPREF0868_1257	Hypothetical protein.	Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.	0.550
ADC91175.1	serS	HMPREF0868_1256	HMPREF0868_1259	Hypothetical protein.	serine--tRNA ligase; Identified by match to protein family HMM PF00587; match to protein family HMM PF02403; match to protein family HMM TIGR00414.	0.425
ADC91249.1	ADC91175.1	HMPREF0868_1258	HMPREF0868_1256	Identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797.	Hypothetical protein.	0.425
ADC91249.1	pepT	HMPREF0868_1258	HMPREF0868_1257	Identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797.	Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.	0.581
ADC91249.1	serS	HMPREF0868_1258	HMPREF0868_1259	Identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797.	serine--tRNA ligase; Identified by match to protein family HMM PF00587; match to protein family HMM PF02403; match to protein family HMM TIGR00414.	0.789
pepT	ADC91175.1	HMPREF0868_1257	HMPREF0868_1256	Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.	Hypothetical protein.	0.550
pepT	ADC91249.1	HMPREF0868_1257	HMPREF0868_1258	Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.	Identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797.	0.581
pepT	serS	HMPREF0868_1257	HMPREF0868_1259	Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.	serine--tRNA ligase; Identified by match to protein family HMM PF00587; match to protein family HMM PF02403; match to protein family HMM TIGR00414.	0.614
serS	ADC91175.1	HMPREF0868_1259	HMPREF0868_1256	serine--tRNA ligase; Identified by match to protein family HMM PF00587; match to protein family HMM PF02403; match to protein family HMM TIGR00414.	Hypothetical protein.	0.425
serS	ADC91249.1	HMPREF0868_1259	HMPREF0868_1258	serine--tRNA ligase; Identified by match to protein family HMM PF00587; match to protein family HMM PF02403; match to protein family HMM TIGR00414.	Identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797.	0.789
serS	pepT	HMPREF0868_1259	HMPREF0868_1257	serine--tRNA ligase; Identified by match to protein family HMM PF00587; match to protein family HMM PF02403; match to protein family HMM TIGR00414.	Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.	0.614

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.905

expected number of edges:

14

PPI enrichment p-value:

1.3e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044038

Cell wall macromolecule biosynthetic process

8 of 29

1.71

3.22

7.08e-10

GO:0009273

Peptidoglycan-based cell wall biogenesis

8 of 30

1.69

3.18

7.08e-10

GO:0071555

Cell wall organization

7 of 24

1.73

3.12

3.50e-09

GO:0009252

Peptidoglycan biosynthetic process

6 of 20

1.74

2.79

7.96e-08

GO:0051301

Cell division

7 of 32

1.61

2.67

1.57e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

4 of 8

1.97

1.94

0.00011

GO:0016874

Ligase activity

5 of 75

1.09

0.76

0.0077

GO:0043168

Anion binding

8 of 334

0.65

0.46

0.0084

GO:0036094

Small molecule binding

8 of 352

0.62

0.44

0.0086

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1122

Peptidoglycan synthesis, and PASTA domain

8 of 12

2.09

5.14

6.38e-13

CL:1121

Cell cycle, and D-Alanine metabolism

9 of 21

1.9

4.64

2.12e-13

CL:1125

Peptidoglycan synthesis, and PASTA domain

4 of 6

2.09

2.58

5.50e-06

CL:1907

Cationic antimicrobial peptide (CAMP) resistance

2 of 5

1.87

0.81

0.0285

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lai00550

Peptidoglycan biosynthesis

7 of 17

1.88

3.76

3.21e-10

lai00473

D-Alanine metabolism

4 of 4

2.27

2.97

1.34e-06

lai01502

Vancomycin resistance

4 of 5

2.17

2.87

1.61e-06

lai00471

D-Glutamine and D-glutamate metabolism

2 of 4

1.97

1.13

0.0067

lai01503

Cationic antimicrobial peptide (CAMP) resistance

2 of 5

1.87

1.08

0.0078

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0961

Cell wall biogenesis/degradation

7 of 13

2.0

4.16

1.32e-10

KW-0573

Peptidoglycan synthesis

6 of 11

2.0

3.67

4.31e-09

KW-0132

Cell division

6 of 30

1.57

2.3

3.26e-07

KW-0131

Cell cycle

6 of 30

1.57

2.3

3.26e-07

KW-0436

Ligase

6 of 63

1.25

1.43

1.25e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

3 of 5

2.05

1.41

0.0019

PF08245

Mur ligase middle domain

3 of 6

1.97

1.39

0.0019

PF01225

Mur ligase family, catalytic domain

2 of 2

2.27

0.97

0.0158

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036615

Mur ligase, C-terminal domain superfamily

3 of 5

2.05

1.18

0.0055

IPR036565

Mur-like, catalytic domain superfamily

3 of 6

1.97

1.17

0.0055

IPR013221

Mur ligase, central

3 of 6

1.97

1.17

0.0055

IPR000713

Mur ligase, N-terminal catalytic domain

2 of 2

2.27

0.8

0.0338

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