STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SRA_04591GTP-pyrophosphokinase; COG2357 Uncharacterized protein conserved in bacteria. (207 aa)    
Predicted Functional Partners:
SRA_04601
COG0642 Signal transduction histidine kinase.
 
   
 0.936
SRA_04991
Putative GTP pyrophosphokinase; COG2357 Uncharacterized protein conserved in bacteria.
  
  
 
0.920
SRA_08866
Putative stringent response protein, ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
 0.912
SRA_04596
COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
   
 0.900
SRA_05171
COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase.
     
  0.900
Pyk
COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family.
     
  0.900
NrdD
COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase.
     
  0.900
folE
COG0302 GTP cyclohydrolase I.
     
  0.800
ribA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
     
  0.800
trmE
tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
   
    0.485
Your Current Organism:
Streptococcus ratti
NCBI taxonomy Id: 699248
Other names: S. ratti FA-1 = DSM 20564, Streptococcus ratti DSM 20564, Streptococcus ratti DSM 20564 = FA-1, Streptococcus ratti FA-1, Streptococcus ratti FA-1 = DSM 20564
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