STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folECOG0302 GTP cyclohydrolase I. (186 aa)    
Predicted Functional Partners:
FolK
Putative 2-amino-4-hydroxy-6-hydroxymethylpteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.
  
 0.998
FolP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 0.990
QueD
COG0720 6-pyruvoyl-tetrahydropterin synthase.
  
 
 0.989
FolB
Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
  
 0.983
ribA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
 
 
 0.952
SRA_04851
Putative folyl-polyglutamate synthetase; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
  
  
 0.833
Pyk
COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family.
    
  0.809
SRA_04591
GTP-pyrophosphokinase; COG2357 Uncharacterized protein conserved in bacteria.
     
  0.800
SRA_04991
Putative GTP pyrophosphokinase; COG2357 Uncharacterized protein conserved in bacteria.
     
  0.800
SRA_05171
COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase.
     
  0.800
Your Current Organism:
Streptococcus ratti
NCBI taxonomy Id: 699248
Other names: S. ratti FA-1 = DSM 20564, Streptococcus ratti DSM 20564, Streptococcus ratti DSM 20564 = FA-1, Streptococcus ratti FA-1, Streptococcus ratti FA-1 = DSM 20564
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