STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AEB06493.1Isochorismatase hydrolase; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR000868; KEGG: afn:Acfer_1559 isochorismatase hydrolase; PFAM: isochorismatase hydrolase; SPTR: Isochorismatase hydrolase; IMG reference gene:2503575154; PFAM: Isochorismatase family. (182 aa)    
Predicted Functional Partners:
AEB06782.1
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
 
 0.962
AEB07492.1
COGs: COG1957 Inosine-uridine nucleoside N-ribohydrolase; InterPro IPR001910; KEGG: cdi:DIP1469 putative nucleoside hydrolase; PFAM: Inosine/uridine-preferring nucleoside hydrolase; SPTR: Possible ribosylpyrimidine nucleosidase; IMG reference gene:2503576207; PFAM: Inosine-uridine preferring nucleoside hydrolase.
    
 0.911
AEB06638.1
COGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845:IPR004402:IPR018016; KEGG: cpy:Cphy_0752 purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; SPTR: Putative uncharacterized protein; TIGRFAM: purine nucleoside phosphorylase; IMG reference gene:2503575304; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD).
    
  0.906
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.686
gpsA
NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; COGs: COG0240 Glycerol-3-phosphate dehydrogenase; InterPro IPR006168:IPR011128:IPR006109; KEGG: apv:Apar_0730 glycerol-3-phosphate dehydrogenase (NAD(P)(+)); PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; SPTR: Glycerol-3-phosphate dehydrogenase; IMG reference gene:2503575708; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  
 
 0.647
AEB06613.1
Transcriptional regulator, AraC family; COGs: COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain; InterPro IPR018060:IPR013096:IPR000005; KEGG: clj:CLJU_c13540 putative AraC family transcriptional regulator; PFAM: helix-turn-helix- domain containing protein AraC type; Cupin 2 conserved barrel domain protein; SMART: Helix-turn-helix, AraC domain; SPTR: AraC family transcriptional regulator; IMG reference gene:2503575279; PFAM: Cupin domain; Bacterial regulatory helix-turn-helix proteins, AraC family.
  
  
 0.619
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.565
rpsL
SSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
  
  
 0.565
glgB
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
  
  
 0.529
nnrD
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
  
    0.523
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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