STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AEB06578.1Thiamine biosynthesis protein ThiF; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594:IPR012729; KEGG: ele:Elen_1748 thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: Thiamine biosynthesis protein ThiF; TIGRFAM: thiamine biosynthesis protein ThiF; IMG reference gene:2503575242; PFAM: ThiF family; TIGRFAM: thiamine biosynthesis protein ThiF, family 2. (209 aa)    
Predicted Functional Partners:
AEB06577.1
Sulfur carrier protein ThiS; InterPro IPR003749:IPR010035; KEGG: ele:Elen_1749 thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; SPTR: Thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; IMG reference gene:2503575241; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
  
 0.996
AEB06579.1
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.988
AEB07024.1
COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR016454:IPR000192; KEGG: apv:Apar_0732 aminotransferase class V; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: Putative uncharacterized protein; IMG reference gene:2503575710; PFAM: Aminotransferase class-V.
   
 0.946
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
    
 0.927
AEB06580.1
COGs: COG0352 Thiamine monophosphate synthase; InterPro IPR003733; KEGG: ele:Elen_1745 thiamine monophosphate synthase; PFAM: thiamine monophosphate synthase; SPTR: Thiamine monophosphate synthase; IMG reference gene:2503575244; PFAM: Thiamine monophosphate synthase/TENI; TIGRFAM: thiamine-phosphate pyrophosphorylase.
 
  
 0.859
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 0.831
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR004532:IPR002547:IPR005121:IPR005146:IPR 005147; KEGG: apv:Apar_1054 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: Putative uncharacterized protein; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; IMG reference gene:2503576306; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta su [...]
  
 
 0.664
AEB06576.1
COGs: COG0596 hydrolase or acyltransferase (alpha/beta hydrolase superfamily); InterPro IPR000073; KEGG: cvi:CV_2920 hydrolase; PFAM: alpha/beta hydrolase fold; SPTR: Putative uncharacterized protein; IMG reference gene:2503575240; PFAM: alpha/beta hydrolase fold.
  
  
 0.635
AEB07330.1
Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR004399:IPR013749; KEGG: ele:Elen_2061 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: Putative uncharacterized protein; TIGRFAM: phosphomethylpyrimidine kinase; IMG reference gene:2503576035; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
  
  
 0.633
AEB07327.1
Hydroxymethylpyrimidine synthase; COGs: COG0422 Thiamine biosynthesis protein ThiC; InterPro IPR002817; KEGG: ele:Elen_2064 thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; SPTR: Phosphomethylpyrimidine synthase; TIGRFAM: thiamine biosynthesis protein ThiC; IMG reference gene:2503576032; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC.
  
  
 0.613
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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