STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (288 aa)    
Predicted Functional Partners:
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.755
AEB07828.1
Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterProIPR004808:IPR020847:IPR020848:IPR005135:IPR 000097; KEGG: apv:Apar_0110 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: Exodeoxyribonuclease III; SPTR: Putative uncharacterized protein; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; IMG reference gene:2503576552; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
   
 
 0.745
AEB06723.1
Exonuclease RecJ; COGs: COG0608 Single-stranded DNA-specific exonuclease; InterProIPR014021:IPR001650:IPR001667:IPR003156:IPR 011545:IPR014001:IPR004610; KEGG: apv:Apar_0519 single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: helicase domain protein; DEAD-like helicase; SPTR: Putative uncharacterized protein; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; IMG reference gene:2503575392; PFAM: DHH family; DHHA1 domain; Helicase conserved C-terminal [...]
  
 
 0.626
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.624
AEB06201.1
DNA-3-methyladenine glycosylase II; COGs: COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase; InterPro IPR003265; KEGG: ccu:Ccur_10470 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase; PFAM: HhH-GPD family protein; SMART: HhH-GPD family protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503574845; PFAM: HhH-GPD superfamily base excision DNA repair protein.
   
 
 0.542
AEB07888.1
DNA polymerase III, epsilon subunit; COGs: COG1199 Rad3-related DNA helicase; InterProIPR006055:IPR014001:IPR006555:IPR014013:IPR 013520:IPR006054; KEGG: apv:Apar_1359 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; DEAD-like helicase; helicase c2; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase III, epsilon subunit; IMG reference gene:2503576617; PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family; DnaQ family exonuclease/DinG family helicase, [...]
  
  
 0.521
AEB07605.1
COGs: COG1227 Inorganic pyrophosphatase/exopolyphosphatase; InterPro IPR000644:IPR010766:IPR004097; KEGG: apv:Apar_0296 putative manganese-dependent inorganic pyrophosphatase; PFAM: CBS domain containing protein; DRTGG domain protein; DHHA2 domain protein; PRIAM: Inorganic diphosphatase; SMART: CBS domain containing protein; SPTR: Possible inorganic diphosphatase; IMG reference gene:2503576325; PFAM: DHH family; DRTGG domain; DHHA2 domain; CBS domain.
  
    0.506
AEB06768.1
NADPH-dependent FMN reductase; COGs: COG0431 flavoprotein; InterPro IPR005025; KEGG: pru:PRU_1694 NADPH-dependent reductase; PFAM: NADPH-dependent FMN reductase; SPTR: NADPH-dependent reductase; IMG reference gene:2503575441; PFAM: NADPH-dependent FMN reductase.
       0.493
rpmI
LSU ribosomal protein L35P; InterPro IPR021137:IPR001706; KEGG: ele:Elen_1234 ribosomal protein L35; PFAM: Ribosomal protein L35; SPTR: 50S ribosomal protein L35; TIGRFAM: ribosomal protein L35; IMG reference gene:2503575398; PFAM: Ribosomal protein L35; TIGRFAM: ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family.
  
  
 0.458
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.431
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.