STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folECOGs: COG0302 GTP cyclohydrolase I; InterPro IPR018234:IPR020602:IPR001474; KEGG: clj:CLJU_c06350 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; IMG reference gene:2503575469; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (186 aa)    
Predicted Functional Partners:
AEB07827.1
COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489:IPR000550:IPR006390; KEGG: apv:Apar_0111 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; SPTR: Putative uncharacterized protein; TIGRFAM: dihydropteroate synthase; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; IMG reference gene:2503576551; PFAM: Pterin binding enzyme; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: dihydropteroate synthase; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase.
  
 0.999
AEB06795.1
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
  
 0.968
AEB06792.1
COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR001150:IPR005144:IPR012833; KEGG: shi:Shel_04760 anaerobic ribonucleoside triphosphate reductase; PFAM: ATP-cone domain protein; formate C-acetyltransferase glycine radical; PRIAM: Ribonucleoside-triphosphate reductase; SPTR: Putative uncharacterized protein; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; IMG reference gene:2503575467; PFAM: Glycine radical; ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase.
    
  0.905
AEB06793.1
Ribonucleoside-triphosphate reductase class III activase subunit; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
  
  
 0.863
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.844
ftsH-2
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
 
  
 0.826
AEB06724.1
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
 0.821
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
 
  
 0.820
AEB06441.1
COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015794:IPR001697; KEGG: apv:Apar_1040 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; IMG reference gene:2503575099; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
    
 0.816
AEB06924.1
FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR013221:IPR001645; KEGG: apv:Apar_0625 FolC bifunctional protein; PFAM: Mur ligase middle domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: FolC bifunctional protein; IMG reference gene:2503575604; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family.
  
  
 0.738
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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