STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB06924.1FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR013221:IPR001645; KEGG: apv:Apar_0625 FolC bifunctional protein; PFAM: Mur ligase middle domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: FolC bifunctional protein; IMG reference gene:2503575604; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (463 aa)    
Predicted Functional Partners:
AEB07827.1
COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489:IPR000550:IPR006390; KEGG: apv:Apar_0111 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; SPTR: Putative uncharacterized protein; TIGRFAM: dihydropteroate synthase; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; IMG reference gene:2503576551; PFAM: Pterin binding enzyme; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: dihydropteroate synthase; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase.
 
 0.999
AEB06931.1
COGs: COG0262 Dihydrofolate reductase; InterPro IPR001796:IPR012259; KEGG: apv:Apar_0631 dihydrofolate reductase region; PFAM: dihydrofolate reductase region; SPTR: Putative uncharacterized protein; IMG reference gene:2503575611; PFAM: Dihydrofolate reductase.
    
 0.941
AEB06930.1
COGs: COG0207 Thymidylate synthase; InterPro IPR000398; KEGG: apv:Apar_0632 thymidylate synthase; PFAM: thymidylate synthase; PRIAM: Thymidylate synthase; SPTR: Putative uncharacterized protein; TIGRFAM: thymidylate synthase; IMG reference gene:2503575610; PFAM: Thymidylate synthase; TIGRFAM: thymidylate synthase.
     
 0.888
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
 
  
 0.814
folE
COGs: COG0302 GTP cyclohydrolase I; InterPro IPR018234:IPR020602:IPR001474; KEGG: clj:CLJU_c06350 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; IMG reference gene:2503575469; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
  
  
 0.738
AEB06795.1
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
  
 0.734
fhs
Formate-tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: ele:Elen_2864 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Formate--tetrahydrofolate ligase; IMG reference gene:2503575964; PFAM: Formate--tetrahydrofolate ligase.
  
 
 0.677
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.636
AEB06923.1
HAD-superfamily hydrolase, subfamily IA, variant 3; COGs: COG0637 phosphatase/phosphohexomutase; InterPro IPR005833:IPR005834:IPR006402; KEGG: cvi:CV_2924 hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Probable hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; IMG reference gene:2503575603; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED.
  
    0.567
AEB06922.1
COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: bmq:BMQ_4506 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; IMG reference gene:2503575602; PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase.
  
  
 0.558
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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