STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB06930.1COGs: COG0207 Thymidylate synthase; InterPro IPR000398; KEGG: apv:Apar_0632 thymidylate synthase; PFAM: thymidylate synthase; PRIAM: Thymidylate synthase; SPTR: Putative uncharacterized protein; TIGRFAM: thymidylate synthase; IMG reference gene:2503575610; PFAM: Thymidylate synthase; TIGRFAM: thymidylate synthase. (282 aa)    
Predicted Functional Partners:
AEB06931.1
COGs: COG0262 Dihydrofolate reductase; InterPro IPR001796:IPR012259; KEGG: apv:Apar_0631 dihydrofolate reductase region; PFAM: dihydrofolate reductase region; SPTR: Putative uncharacterized protein; IMG reference gene:2503575611; PFAM: Dihydrofolate reductase.
 
 
 0.998
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 0.967
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.936
folD
5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.935
AEB06322.1
Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726; KEGG: sth:STH2500 5-methyltetrahydrofolate S-homocysteine methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: Putative uncharacterized protein; IMG reference gene:2503574970; PFAM: Homocysteine S-methyltransferase.
  
 
 0.924
tgt
tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...]
 
    0.908
AEB06924.1
FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR013221:IPR001645; KEGG: apv:Apar_0625 FolC bifunctional protein; PFAM: Mur ligase middle domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: FolC bifunctional protein; IMG reference gene:2503575604; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family.
     
 0.888
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.760
AEB06932.1
Hypothetical protein; KEGG: apv:Apar_0227 flavodoxin; SPTR: Putative uncharacterized protein; IMG reference gene:2503575612.
 
     0.747
AEB06933.1
tRNA/rRNA methyltransferase (SpoU); COGs: COG0566 rRNA methylase; InterPro IPR001537; KEGG: shi:Shel_05470 rRNA methylase; PFAM: tRNA/rRNA methyltransferase (SpoU); SPTR: Putative uncharacterized protein; IMG reference gene:2503575613; PFAM: SpoU rRNA Methylase family.
       0.720
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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