STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (426 aa)    
Predicted Functional Partners:
AEB06134.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.943
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
 
 
 0.801
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.798
AEB06896.1
Transcriptional regulator, XRE family; COGs: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidase); InterPro IPR001387:IPR019759; KEGG: apv:Apar_0551 transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; Peptidase S24/S26A/S26B, conserved region; SMART: helix-turn-helix domain protein; SPTR: Transcriptional regulator, XRE family; IMG reference gene:2503575572; PFAM: Helix-turn-helix; Peptidase S24-like.
 
 
 0.739
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.733
AEB07747.1
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR017896:IPR011895:IPR017900:IPR002880:IPR 019752:IPR019456:IPR011766; KEGG: apv:Apar_1328 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Putative uncharacterized protein; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; [...]
   
 
 0.718
AEB07755.1
Peptidoglycan glycosyltransferase; COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR001182:IPR005311:IPR001460; KEGG: apv:Apar_1344 peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; cell cycle protein; Penicillin-binding protein dimerisation domain; PRIAM: Peptidoglycan glycosyltransferase; SPTR: Putative uncharacterized protein; IMG reference gene:2503576476; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain; Cell cycle protein; Belongs to the SEDS family.
  
 
 0.691
AEB06874.1
Cell cycle protein; COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR001182; KEGG: apv:Apar_0484 cell cycle protein; PFAM: cell cycle protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503575549; PFAM: Cell cycle protein; TIGRFAM: cell division protein FtsW; Belongs to the SEDS family.
  
 
 0.682
AEB06358.1
Transcriptional regulator, XRE family; COGs: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidase); InterPro IPR001387:IPR019759; KEGG: ccu:Ccur_03030 SOS response transcriptional repressor, RecA-mediated autopeptidase; PFAM: helix-turn-helix domain protein; Peptidase S24/S26A/S26B, conserved region; SMART: helix-turn-helix domain protein; SPTR: Putative prophage L54a, repressor protein; IMG reference gene:2503575010; PFAM: Helix-turn-helix; Peptidase S24-like.
  
 
 0.668
AEB06970.1
Cell elongation-specific peptidoglycan biosynthesis regulator RodA; COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR001182; KEGG: apv:Apar_0674 cell cycle protein; PFAM: cell cycle protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503575651; PFAM: Cell cycle protein; Belongs to the SEDS family.
  
 
 0.667
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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