STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ispHHydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (282 aa)    
Predicted Functional Partners:
ispG
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
 
 
 0.989
cmk
COGs: COG0283 Cytidylate kinase; InterPro IPR011994:IPR003136; KEGG: apv:Apar_0725 cytidylate kinase; PFAM: cytidylate kinase region; SPTR: Cytidylate kinase; TIGRFAM: cytidylate kinase; IMG reference gene:2503575703; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase.
      0.981
AEB06248.1
NUDIX hydrolase; COGs: COG1443 Isopentenyldiphosphate isomerase; InterPro IPR000086; KEGG: ttu:TERTU_3249 isopentenyl-diphosphate delta-isomerase; PFAM: NUDIX hydrolase; SPTR: Putative uncharacterized protein; IMG reference gene:2503574895; PFAM: NUDIX domain; TIGRFAM: isopentenyl-diphosphate delta-isomerase, type 1.
    
 0.946
AEB06331.1
COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: ele:Elen_0577 polyprenyl synthetase; PFAM: Polyprenyl synthetase; SPTR: Putative uncharacterized protein; IMG reference gene:2503574983; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
  
 
 0.940
AEB07306.1
COGs: COG0539 Ribosomal protein S1; InterPro IPR000110:IPR003029; KEGG: apv:Apar_0962 RNA binding S1 domain protein; PFAM: RNA binding S1 domain protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503576010; PFAM: S1 RNA binding domain; TIGRFAM: ribosomal protein S1.
 
  
 0.923
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
 
   
 0.878
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
 
   
 0.878
ispE
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
 
   
 0.869
AEB07016.1
Ribosomal large subunit pseudouridine synthase B; COGs: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthase; InterPro IPR002942:IPR018496:IPR006145:IPR000748; KEGG: ele:Elen_1330 pseudouridine synthase; PFAM: pseudouridine synthase; RNA-binding S4 domain protein; SMART: RNA-binding S4 domain protein; SPTR: Pseudouridine synthase; IMG reference gene:2503575702; PFAM: RNA pseudouridylate synthase; S4 domain; TIGRFAM: pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.
       0.818
AEB07018.1
COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123; KEGG: apv:Apar_0725 cytidylate kinase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; SPTR: Putative uncharacterized protein; IMG reference gene:2503575704; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases.
     
 0.816
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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