STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
lexASOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (211 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.896
dinB
DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.801
AEB07081.1
Protein of unknown function DUF1624; COGs: COG3503 membrane protein; InterPro IPR012429; KEGG: apv:Apar_0771 protein of unknown function DUF1624; PFAM: protein of unknown function DUF1624; SPTR: Putative uncharacterized protein; IMG reference gene:2503575771; PFAM: Protein of unknown function (DUF1624).
       0.791
AEB06812.1
COGs: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; InterPro IPR017963:IPR001126; KEGG: ele:Elen_1465 UMUC domain protein DNA-repair protein; PFAM: UMUC domain protein DNA-repair protein; PRIAM: DNA-directed DNA polymerase; SPTR: Putative uncharacterized protein; IMG reference gene:2503575487; PFAM: IMS family HHH motif; impB/mucB/samB family.
 
 
 0.773
AEB07079.1
Peptidoglycan-binding lysin domain protein; InterPro IPR018392; KEGG: apv:Apar_0769 peptidoglycan-binding LysM; PFAM: Peptidoglycan-binding lysin domain; SPTR: Putative uncharacterized protein; IMG reference gene:2503575769; PFAM: LysM domain.
  
  
 0.675
AEB06613.1
Transcriptional regulator, AraC family; COGs: COG4977 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain; InterPro IPR018060:IPR013096:IPR000005; KEGG: clj:CLJU_c13540 putative AraC family transcriptional regulator; PFAM: helix-turn-helix- domain containing protein AraC type; Cupin 2 conserved barrel domain protein; SMART: Helix-turn-helix, AraC domain; SPTR: AraC family transcriptional regulator; IMG reference gene:2503575279; PFAM: Cupin domain; Bacterial regulatory helix-turn-helix proteins, AraC family.
  
 
 0.668
AEB07097.1
DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA.
  
  
 0.649
ruvA
Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
  
  
 0.555
uvrC
Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
  
 0.542
AEB07888.1
DNA polymerase III, epsilon subunit; COGs: COG1199 Rad3-related DNA helicase; InterProIPR006055:IPR014001:IPR006555:IPR014013:IPR 013520:IPR006054; KEGG: apv:Apar_1359 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; DEAD-like helicase; helicase c2; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase III, epsilon subunit; IMG reference gene:2503576617; PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family; DnaQ family exonuclease/DinG family helicase, [...]
  
  
 0.533
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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