STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (189 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.979
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
  
 0.967
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.965
AEB06184.1
COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836:IPR005904; KEGG: apv:Apar_0107 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: hypoxanthine phosphoribosyltransferase; IMG reference gene:2503574827; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.950
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.937
AEB06441.1
COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015794:IPR001697; KEGG: apv:Apar_1040 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; IMG reference gene:2503575099; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.926
AEB06724.1
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.925
AEB07131.1
KEGG: apv:Apar_0809 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503575821.
  
  
 0.879
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
  
 0.845
AEB07602.1
COGs: COG0514 Superfamily II DNA helicase; InterProIPR018329:IPR002121:IPR014021:IPR001650:IPR 011545:IPR018982:IPR014001; KEGG: ele:Elen_1066 ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; RQC domain; HRDC domain protein; SMART: helicase domain protein; DEAD-like helicase; HRDC domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: ATP-dependent DNA helicase, RecQ family; IMG reference gene:2503576322; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA [...]
  
 
 0.832
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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