STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (220 aa)    
Predicted Functional Partners:
AEB07828.1
Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterProIPR004808:IPR020847:IPR020848:IPR005135:IPR 000097; KEGG: apv:Apar_0110 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: Exodeoxyribonuclease III; SPTR: Putative uncharacterized protein; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; IMG reference gene:2503576552; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
 
 0.995
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.777
nfo
Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
  
 
 0.755
AEB06207.1
COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR017969; KEGG: pca:Pcar_2431 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503574851; TIGRFAM: TIGR00268 family protein.
 
    0.659
AEB07888.1
DNA polymerase III, epsilon subunit; COGs: COG1199 Rad3-related DNA helicase; InterProIPR006055:IPR014001:IPR006555:IPR014013:IPR 013520:IPR006054; KEGG: apv:Apar_1359 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; DEAD-like helicase; helicase c2; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase III, epsilon subunit; IMG reference gene:2503576617; PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family; DnaQ family exonuclease/DinG family helicase, [...]
  
  
 0.648
AEB06723.1
Exonuclease RecJ; COGs: COG0608 Single-stranded DNA-specific exonuclease; InterProIPR014021:IPR001650:IPR001667:IPR003156:IPR 011545:IPR014001:IPR004610; KEGG: apv:Apar_0519 single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: helicase domain protein; DEAD-like helicase; SPTR: Putative uncharacterized protein; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; IMG reference gene:2503575392; PFAM: DHH family; DHHA1 domain; Helicase conserved C-terminal [...]
  
  
 0.587
AEB07689.1
Protein of unknown function DUF195; COGs: COG1322 conserved hypothetical protein; InterPro IPR003798; KEGG: apv:Apar_0434 protein of unknown function DUF195; PFAM: protein of unknown function DUF195; SPTR: Putative uncharacterized protein; IMG reference gene:2503576409; PFAM: RmuC family.
       0.583
AEB07720.1
COGs: COG1194 A/G-specific DNA glycosylase; InterPro IPR003265:IPR004036; KEGG: apv:Apar_0121 HhH-GPD family protein; PFAM: HhH-GPD family protein; SMART: HhH-GPD family protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503576440; PFAM: HhH-GPD superfamily base excision DNA repair protein.
 
  
0.567
AEB07086.1
InterPro IPR003594; KEGG: apv:Apar_0776 ATP-binding region ATPase domain protein; PFAM: ATP-binding region ATPase domain protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503575776; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
   
 
 0.546
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
    0.514
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.