STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas1-2CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (292 aa)    
Predicted Functional Partners:
cas2
CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.989
cas9
CRISPR-associated protein, Csn1 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans- encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this [...]
 
   
 0.959
AEB06545.1
CRISPR-associated protein Cas2; InterPro IPR010152; KEGG: nml:Namu_3048 CRISPR-associated protein Cas2; PFAM: CRISPR-associated protein Cas2; SPTR: Putative uncharacterized protein; TIGRFAM: CRISPR-associated protein Cas2; manually curated; IMG reference gene:2503575209; PFAM: CRISPR-associated protein (Cas_Cas2CT1978); TIGRFAM: CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI.
  
 
 0.836
AEB07836.1
Hypothetical protein; KEGG: tde:TDE0330 CRISPR-associated Csn2 family protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503576561; PFAM: CRISPR-associated protein (Cas_Csn2); TIGRFAM: CRISPR type II-A/NMEMI-associated protein Csn2.
       0.721
AEB06539.1
CRISPR-associated protein, Cse1 family; InterPro IPR013381; KEGG: nfa:nfa44270 hypothetical protein; PFAM: CRISPR-associated protein Cse1; SPTR: Putative uncharacterized protein; TIGRFAM: CRISPR-associated protein, Cse1 family; IMG reference gene:2503575203; PFAM: CRISPR-associated protein Cse1 (CRISPR_cse1); TIGRFAM: CRISPR type I-E/ECOLI-associated protein CasA/Cse1.
  
  
 0.522
AEB06543.1
InterPro IPR010179; KEGG: nml:Namu_3050 CRISPR-associated protein, CSE3 family; PFAM: CRISPR-associated protein CT1974; SPTR: Putative uncharacterized protein; TIGRFAM: CRISPR-associated protein, Cse3 family; IMG reference gene:2503575207; PFAM: CRISPR associated protein; TIGRFAM: CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI.
  
  
 0.522
AEB06541.1
InterPro IPR010148; KEGG: nml:Namu_3052 CRISPR-associated protein, CSE4 family; PFAM: CRISPR-associated protein CT1975; SPTR: CRISPR-associated protein, Cse4 family; TIGRFAM: CRISPR-associated protein, Cse4 family; IMG reference gene:2503575205; PFAM: CT1975-like protein; TIGRFAM: CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI.
  
  
 0.491
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
   0.484
AEB07390.1
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683; KEGG: gct:GC56T3_3239 oxidoreductase domain protein; PFAM: oxidoreductase domain protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503576100; PFAM: Oxidoreductase family, NAD-binding Rossmann fold.
  
 
 0.457
AEB07601.1
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683; KEGG: apv:Apar_0125 oxidoreductase domain protein; PFAM: oxidoreductase domain protein; SPTR: Putative uncharacterized protein; IMG reference gene:2503576321; PFAM: Oxidoreductase family, NAD-binding Rossmann fold.
  
 
 0.457
Your Current Organism:
Coriobacterium glomerans
NCBI taxonomy Id: 700015
Other names: C. glomerans PW2, Coriobacterium glomerans DSM 20642, Coriobacterium glomerans PW2, Coriobacterium glomerans str. PW2, Coriobacterium glomerans strain PW2
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