node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEV96765.1 | AEV96767.1 | Niako_0367 | Niako_0369 | Hypothetical protein. | PFAM: AhpC/TSA family; InterPro IPR000866; KEGG: shg:Sph21_0742 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Thioredoxin family protein. | 0.762 |
AEV96765.1 | hisA | Niako_0367 | Niako_0365 | Hypothetical protein. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Acetyltransferase (GNAT) family; Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR000182:IPR006062; KEGG: cpi:Cpin_1830 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: [...] | 0.454 |
AEV96765.1 | hisF | Niako_0367 | Niako_0366 | Hypothetical protein. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.773 |
AEV96765.1 | hisH | Niako_0367 | Niako_0364 | Hypothetical protein. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.454 |
AEV96765.1 | hisI | Niako_0367 | Niako_0368 | Hypothetical protein. | PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: mtt:Ftrac_3210 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.762 |
AEV96765.1 | trpA | Niako_0367 | Niako_0363 | Hypothetical protein. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.451 |
AEV96767.1 | AEV96765.1 | Niako_0369 | Niako_0367 | PFAM: AhpC/TSA family; InterPro IPR000866; KEGG: shg:Sph21_0742 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Thioredoxin family protein. | Hypothetical protein. | 0.762 |
AEV96767.1 | hisA | Niako_0369 | Niako_0365 | PFAM: AhpC/TSA family; InterPro IPR000866; KEGG: shg:Sph21_0742 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Thioredoxin family protein. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Acetyltransferase (GNAT) family; Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR000182:IPR006062; KEGG: cpi:Cpin_1830 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: [...] | 0.486 |
AEV96767.1 | hisF | Niako_0369 | Niako_0366 | PFAM: AhpC/TSA family; InterPro IPR000866; KEGG: shg:Sph21_0742 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Thioredoxin family protein. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.781 |
AEV96767.1 | hisH | Niako_0369 | Niako_0364 | PFAM: AhpC/TSA family; InterPro IPR000866; KEGG: shg:Sph21_0742 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Thioredoxin family protein. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.492 |
AEV96767.1 | hisI | Niako_0369 | Niako_0368 | PFAM: AhpC/TSA family; InterPro IPR000866; KEGG: shg:Sph21_0742 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Thioredoxin family protein. | PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: mtt:Ftrac_3210 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.819 |
AEV96767.1 | trpA | Niako_0369 | Niako_0363 | PFAM: AhpC/TSA family; InterPro IPR000866; KEGG: shg:Sph21_0742 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Thioredoxin family protein. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.494 |
hisA | AEV96765.1 | Niako_0365 | Niako_0367 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Acetyltransferase (GNAT) family; Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR000182:IPR006062; KEGG: cpi:Cpin_1830 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: [...] | Hypothetical protein. | 0.454 |
hisA | AEV96767.1 | Niako_0365 | Niako_0369 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Acetyltransferase (GNAT) family; Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR000182:IPR006062; KEGG: cpi:Cpin_1830 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: [...] | PFAM: AhpC/TSA family; InterPro IPR000866; KEGG: shg:Sph21_0742 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Thioredoxin family protein. | 0.486 |
hisA | hisF | Niako_0365 | Niako_0366 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Acetyltransferase (GNAT) family; Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR000182:IPR006062; KEGG: cpi:Cpin_1830 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: [...] | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.996 |
hisA | hisH | Niako_0365 | Niako_0364 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Acetyltransferase (GNAT) family; Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR000182:IPR006062; KEGG: cpi:Cpin_1830 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: [...] | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Niako_0365 | Niako_0368 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Acetyltransferase (GNAT) family; Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR000182:IPR006062; KEGG: cpi:Cpin_1830 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: [...] | PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: mtt:Ftrac_3210 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | trpA | Niako_0365 | Niako_0363 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Acetyltransferase (GNAT) family; Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR000182:IPR006062; KEGG: cpi:Cpin_1830 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: [...] | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.874 |
hisF | AEV96765.1 | Niako_0366 | Niako_0367 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Hypothetical protein. | 0.773 |
hisF | AEV96767.1 | Niako_0366 | Niako_0369 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | PFAM: AhpC/TSA family; InterPro IPR000866; KEGG: shg:Sph21_0742 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen; PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Thioredoxin family protein. | 0.781 |