STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AEW00509.1Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846:IPR012001:IPR012000:IPR011766; KEGG: cpi:Cpin_6128 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyro [...] (574 aa)    
Predicted Functional Partners:
AEV96506.1
PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit; COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789:IPR002912:IPR019455; KEGG: phe:Phep_3420 acetolactate synthase small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; SPTR: Acetohydroxyacid synthase small subunit; TIGRFAM: Acetolactate synthase, small subunit.
 
 0.999
AEV96507.1
Ketol-acid reductoisomerase; PFAM: Acetohydroxy acid isomeroreductase, catalytic domain; TIGRFAM: ketol-acid reductoisomerase; COGs: COG0059 Ketol-acid reductoisomerase; InterPro IPR013023:IPR013116:IPR000506; KEGG: osp:Odosp_2905 ketol-acid reductoisomerase; PFAM: Acetohydroxy acid isomeroreductase, catalytic; Acetohydroxy acid isomeroreductase C-terminal; SPTR: Ketol-acid reductoisomerase; TIGRFAM: Acetohydroxy acid isomeroreductase.
 
 
 0.994
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.984
leuB-2
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.983
AEV96664.1
PFAM: Alpha-acetolactate decarboxylase; TIGRFAM: alpha-acetolactate decarboxylase; COGs: COG3527 Alpha-acetolactate decarboxylase; InterPro IPR005128; KEGG: mma:MM_0639 alpha-acetolactate decarboxylase; PFAM: Alpha-acetolactate decarboxylase; PRIAM: Acetolactate decarboxylase; SPTR: Alpha-acetolactate decarboxylase.
  
 
 0.979
AEV96501.1
2-isopropylmalate synthase; PFAM: HMGL-like; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: bsa:Bacsa_2893 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; PRIAM: 2-isopropylmalate synthase; SPTR: 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.971
ilvD
PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: shg:Sph21_2290 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 0.965
AEV99021.1
(R)-citramalate synthase; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: dfe:Dfer_3672 pyruvate carboxyltransferase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.964
ilvA
L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
 
 0.963
AEV97630.1
PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...]
  
 
 0.948
Your Current Organism:
Niastella koreensis
NCBI taxonomy Id: 700598
Other names: N. koreensis GR20-10, Niastella koreensis DSM 17620, Niastella koreensis GR20-10, Niastella koreensis NBRC 106392, Niastella koreensis str. GR20-10, Niastella koreensis strain GR20-10
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