node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEV99322.1 | AEW00981.1 | Niako_2992 | Niako_4725 | PFAM: ATP-dependent Clp protease adaptor protein ClpS; InterPro IPR003769; KEGG: cpi:Cpin_6581 ATP-dependent Clp protease adaptor protein ClpS; PFAM: Adaptor protein ClpS, core; SPTR: ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | 0.893 |
AEV99322.1 | clpP | Niako_2992 | Niako_4007 | PFAM: ATP-dependent Clp protease adaptor protein ClpS; InterPro IPR003769; KEGG: cpi:Cpin_6581 ATP-dependent Clp protease adaptor protein ClpS; PFAM: Adaptor protein ClpS, core; SPTR: ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.476 |
AEV99322.1 | clpP-2 | Niako_2992 | Niako_6973 | PFAM: ATP-dependent Clp protease adaptor protein ClpS; InterPro IPR003769; KEGG: cpi:Cpin_6581 ATP-dependent Clp protease adaptor protein ClpS; PFAM: Adaptor protein ClpS, core; SPTR: ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.476 |
AEV99322.1 | clpP-3 | Niako_2992 | Niako_6974 | PFAM: ATP-dependent Clp protease adaptor protein ClpS; InterPro IPR003769; KEGG: cpi:Cpin_6581 ATP-dependent Clp protease adaptor protein ClpS; PFAM: Adaptor protein ClpS, core; SPTR: ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.476 |
AEW00981.1 | AEV99322.1 | Niako_4725 | Niako_2992 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | PFAM: ATP-dependent Clp protease adaptor protein ClpS; InterPro IPR003769; KEGG: cpi:Cpin_6581 ATP-dependent Clp protease adaptor protein ClpS; PFAM: Adaptor protein ClpS, core; SPTR: ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | 0.893 |
AEW00981.1 | AEW01359.1 | Niako_4725 | Niako_5120 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.820 |
AEW00981.1 | AEW01426.1 | Niako_4725 | Niako_5189 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | PFAM: Hsp70 protein; COGs: COG0443 Molecular chaperone; InterPro IPR013126; KEGG: cly:Celly_2124 heat shock protein 70; PFAM: Heat shock protein 70; SPTR: Chaperone DnaK. | 0.960 |
AEW00981.1 | clpP | Niako_4725 | Niako_4007 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.910 |
AEW00981.1 | clpP-2 | Niako_4725 | Niako_6973 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.915 |
AEW00981.1 | clpP-3 | Niako_4725 | Niako_6974 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.910 |
AEW00981.1 | dnaJ | Niako_4725 | Niako_5504 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.792 |
AEW00981.1 | dnaK | Niako_4725 | Niako_2097 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.960 |
AEW00981.1 | grpE | Niako_4725 | Niako_5503 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.822 |
AEW00981.1 | lon | Niako_4725 | Niako_3686 | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | Anti-sigma H sporulation factor, LonB; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.793 |
AEW01359.1 | AEW00981.1 | Niako_5120 | Niako_4725 | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; UvrB/uvrC motif; ATPase family associated with various cellular activities (AAA); COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 doma [...] | 0.820 |
AEW01359.1 | AEW01426.1 | Niako_5120 | Niako_5189 | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | PFAM: Hsp70 protein; COGs: COG0443 Molecular chaperone; InterPro IPR013126; KEGG: cly:Celly_2124 heat shock protein 70; PFAM: Heat shock protein 70; SPTR: Chaperone DnaK. | 0.989 |
AEW01359.1 | dnaJ | Niako_5120 | Niako_5504 | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.978 |
AEW01359.1 | dnaK | Niako_5120 | Niako_2097 | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.989 |
AEW01359.1 | grpE | Niako_5120 | Niako_5503 | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.827 |
AEW01359.1 | lon | Niako_5120 | Niako_3686 | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | Anti-sigma H sporulation factor, LonB; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.806 |