node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEV96968.1 | AEV97630.1 | Niako_0573 | Niako_1259 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | 0.950 |
AEV96968.1 | AEV98632.1 | Niako_0573 | Niako_2284 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Dihydrolipoyllysine-residue acetyltransferase; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: dps:DPPB40 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; E3 binding; Biotin/lipoyl attachment; PRIAM: Dihydrolipoyllysine-residue acetyltransferase; SPTR: Probable pyruvate dehydrogenase, E2 component, dih [...] | 0.831 |
AEV96968.1 | AEV98635.1 | Niako_0573 | Niako_2287 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Acetate--CoA ligase; PFAM: AMP-binding enzyme; COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: dps:DP2097 acetyl-CoA synthetase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Acetate--CoA ligase; SPTR: Probable acetyl-CoA synthetase. | 0.847 |
AEV96968.1 | AEW01692.1 | Niako_0573 | Niako_5457 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; COGs: COG0372 Citrate synthase; InterPro IPR010109:IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; TIGRFAM: Citrate synthase, eukaryotic; Belongs to the citrate synthase family. | 0.953 |
AEV96968.1 | AEW01758.1 | Niako_0573 | Niako_5523 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.831 |
AEV96968.1 | AEW02886.1 | Niako_0573 | Niako_6662 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.847 |
AEV96968.1 | mdh | Niako_0573 | Niako_0304 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.934 |
AEV96968.1 | mqo | Niako_0573 | Niako_1825 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | PFAM: Malate:quinone oxidoreductase (Mqo); TIGRFAM: malate:quinone-oxidoreductase; COGs: COG0579 dehydrogenase; HAMAP: Malate:quinone-oxidoreductase; InterPro IPR006231; KEGG: sli:Slin_2679 malate/quinone oxidoreductase; PFAM: Malate:quinone-oxidoreductase; PRIAM: Malate dehydrogenase (acceptor); SPTR: Probable malate:quinone oxidoreductase; TIGRFAM: Malate:quinone-oxidoreductase. | 0.923 |
AEV97630.1 | AEV96968.1 | Niako_1259 | Niako_0573 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.950 |
AEV97630.1 | AEV98632.1 | Niako_1259 | Niako_2284 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | Dihydrolipoyllysine-residue acetyltransferase; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: dps:DPPB40 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; E3 binding; Biotin/lipoyl attachment; PRIAM: Dihydrolipoyllysine-residue acetyltransferase; SPTR: Probable pyruvate dehydrogenase, E2 component, dih [...] | 0.938 |
AEV97630.1 | AEV98635.1 | Niako_1259 | Niako_2287 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | Acetate--CoA ligase; PFAM: AMP-binding enzyme; COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873; KEGG: dps:DP2097 acetyl-CoA synthetase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Acetate--CoA ligase; SPTR: Probable acetyl-CoA synthetase. | 0.956 |
AEV97630.1 | AEW00740.1 | Niako_1259 | Niako_4481 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: aconitate hydratase, mitochondrial; COGs: COG1048 Aconitase A; InterPro IPR006248:IPR001030:IPR000573; KEGG: cpi:Cpin_2016 aconitate hydratase; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: Aconitate hydratase; TIGRFAM: Aconitase, mitochondrial-like. | 0.573 |
AEV97630.1 | AEW01692.1 | Niako_1259 | Niako_5457 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; COGs: COG0372 Citrate synthase; InterPro IPR010109:IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; TIGRFAM: Citrate synthase, eukaryotic; Belongs to the citrate synthase family. | 0.968 |
AEV97630.1 | AEW01758.1 | Niako_1259 | Niako_5523 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.938 |
AEV97630.1 | AEW02886.1 | Niako_1259 | Niako_6662 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.956 |
AEV97630.1 | mdh | Niako_1259 | Niako_0304 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.903 |
AEV97630.1 | mqo | Niako_1259 | Niako_1825 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | PFAM: Malate:quinone oxidoreductase (Mqo); TIGRFAM: malate:quinone-oxidoreductase; COGs: COG0579 dehydrogenase; HAMAP: Malate:quinone-oxidoreductase; InterPro IPR006231; KEGG: sli:Slin_2679 malate/quinone oxidoreductase; PFAM: Malate:quinone-oxidoreductase; PRIAM: Malate dehydrogenase (acceptor); SPTR: Probable malate:quinone oxidoreductase; TIGRFAM: Malate:quinone-oxidoreductase. | 0.479 |
AEV97630.1 | sucC | Niako_1259 | Niako_0380 | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.935 |
AEV98632.1 | AEV96968.1 | Niako_2284 | Niako_0573 | Dihydrolipoyllysine-residue acetyltransferase; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: dps:DPPB40 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; E3 binding; Biotin/lipoyl attachment; PRIAM: Dihydrolipoyllysine-residue acetyltransferase; SPTR: Probable pyruvate dehydrogenase, E2 component, dih [...] | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.831 |
AEV98632.1 | AEV97630.1 | Niako_2284 | Niako_1259 | Dihydrolipoyllysine-residue acetyltransferase; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: dps:DPPB40 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; E3 binding; Biotin/lipoyl attachment; PRIAM: Dihydrolipoyllysine-residue acetyltransferase; SPTR: Probable pyruvate dehydrogenase, E2 component, dih [...] | PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895:IPR002880:IPR019752:IPR019456:IPR 001450:IPR011766; KEGG: mca:MCA0769 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Py [...] | 0.938 |