STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III, DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa)    
Predicted Functional Partners:
AEW02248.1
Exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth); COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR000097:IPR004808; KEGG: cpi:Cpin_0890 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: Exodeoxyribonuclease III; SPTR: Exodeoxyribonuclease III Xth; TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1.
 
 0.938
AEV96921.1
DNA-(apurinic or apyrimidinic site) lyase; PFAM: HhH-GPD superfamily base excision DNA repair protein; COGs: COG0177 EndoIII-related endonuclease; InterPro IPR003265; KEGG: fjo:Fjoh_2740 DNA-(apurinic or apyrimidinic site) lyase; PFAM: HhH-GPD domain; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SMART: HhH-GPD domain; SPTR: DNA-(Apurinic or apyrimidinic site) lyase / endonuclease III.
  
  
 
0.918
AEV98018.1
Exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth); COGs: COG0708 Exonuclease III; InterPro IPR000097:IPR004808:IPR005135; KEGG: cpi:Cpin_3378 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: Exodeoxyribonuclease III; SPTR: Exodeoxyribonuclease III; TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1.
 
 0.838
AEW02171.1
PFAM: Endonuclease/Exonuclease/phosphatase family; COGs: COG0708 Exonuclease III; InterPro IPR005135; KEGG: phe:Phep_1385 endonuclease/exonuclease/phosphatase; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Endonuclease/exonuclease/phosphatase.
  
 0.733
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 0.632
AEW02936.1
DNA glycosylase/AP lyase, H2TH DNA-binding protein; PFAM: Formamidopyrimidine-DNA glycosylase H2TH domain; Formamidopyrimidine-DNA glycosylase N-terminal domain; COGs: COG0266 Formamidopyrimidine-DNA glycosylase; InterPro IPR012319:IPR015886; KEGG: cpi:Cpin_6307 DNA glycosylase/AP lyase, H2TH DNA-binding; PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; DNA glycosylase/AP lyase, catalytic domain; SPTR: DNA glycosylase/AP lyase, H2TH DNA-binding.
   
  
 0.605
AEW02876.1
KEGG: mtt:Ftrac_2181 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.596
ung
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
  
 
 0.515
AEW00782.1
PFAM: Periplasmic binding protein; COGs: COG0614 ABC-type Fe3+-hydroxamate transport system periplasmic component; InterPro IPR002491; KEGG: cpi:Cpin_3666 periplasmic binding protein; PFAM: Periplasmic binding protein; SPTR: Periplasmic binding protein.
      0.479
AEW02817.1
Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
 
   
 0.459
Your Current Organism:
Niastella koreensis
NCBI taxonomy Id: 700598
Other names: N. koreensis GR20-10, Niastella koreensis DSM 17620, Niastella koreensis GR20-10, Niastella koreensis NBRC 106392, Niastella koreensis str. GR20-10, Niastella koreensis strain GR20-10
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.