| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADO46387.1 | dut | Entcl_0109 | Entcl_0108 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.974 |
| ADO46387.1 | slmA | Entcl_0109 | Entcl_0107 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Regulatory protein TetR; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.620 |
| ADO46651.1 | slmA | Entcl_0373 | Entcl_0107 | PFAM: protein of unknown function UPF0270; KEGG: kva:Kvar_0362 protein of unknown function UPF0270; Belongs to the UPF0270 family. | Regulatory protein TetR; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.525 |
| ADO49769.1 | ADO50465.1 | Entcl_3527 | Entcl_4232 | PFAM: Methyltransferase type 11; KEGG: kva:Kvar_4159 methyltransferase type 11. | KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX. | 0.458 |
| ADO49769.1 | seqA | Entcl_3527 | Entcl_3128 | PFAM: Methyltransferase type 11; KEGG: kva:Kvar_4159 methyltransferase type 11. | SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.641 |
| ADO49769.1 | slmA | Entcl_3527 | Entcl_0107 | PFAM: Methyltransferase type 11; KEGG: kva:Kvar_4159 methyltransferase type 11. | Regulatory protein TetR; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.497 |
| ADO50393.1 | ADO50465.1 | Entcl_4160 | Entcl_4232 | PFAM: protein of unknown function DUF416; KEGG: kva:Kvar_4861 protein of unknown function DUF416. | KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX. | 0.644 |
| ADO50393.1 | seqA | Entcl_4160 | Entcl_3128 | PFAM: protein of unknown function DUF416; KEGG: kva:Kvar_4861 protein of unknown function DUF416. | SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.723 |
| ADO50393.1 | slmA | Entcl_4160 | Entcl_0107 | PFAM: protein of unknown function DUF416; KEGG: kva:Kvar_4861 protein of unknown function DUF416. | Regulatory protein TetR; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.533 |
| ADO50465.1 | ADO49769.1 | Entcl_4232 | Entcl_3527 | KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX. | PFAM: Methyltransferase type 11; KEGG: kva:Kvar_4159 methyltransferase type 11. | 0.458 |
| ADO50465.1 | ADO50393.1 | Entcl_4232 | Entcl_4160 | KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX. | PFAM: protein of unknown function DUF416; KEGG: kva:Kvar_4861 protein of unknown function DUF416. | 0.644 |
| ADO50465.1 | slmA | Entcl_4232 | Entcl_0107 | KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX. | Regulatory protein TetR; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.487 |
| dut | ADO46387.1 | Entcl_0108 | Entcl_0109 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.974 |
| dut | slmA | Entcl_0108 | Entcl_0107 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Regulatory protein TetR; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.840 |
| flhC | flhD | Entcl_1902 | Entcl_1901 | Flagellar transcriptional activator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. | Flagellar transcriptional activator; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. | 0.999 |
| flhC | slmA | Entcl_1902 | Entcl_0107 | Flagellar transcriptional activator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. | Regulatory protein TetR; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.663 |
| flhD | flhC | Entcl_1901 | Entcl_1902 | Flagellar transcriptional activator; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. | Flagellar transcriptional activator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. | 0.999 |
| flhD | slmA | Entcl_1901 | Entcl_0107 | Flagellar transcriptional activator; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. | Regulatory protein TetR; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.536 |
| ftsZ | slmA | Entcl_3631 | Entcl_0107 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Regulatory protein TetR; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.720 |
| seqA | ADO49769.1 | Entcl_3128 | Entcl_3527 | SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | PFAM: Methyltransferase type 11; KEGG: kva:Kvar_4159 methyltransferase type 11. | 0.641 |
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