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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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ADO46979.1Manually curated; PFAM: SH3 type 3 domain protein; KEGG: kpu:KP1_4746 putative signal transduction protein; SMART: SH3 domain protein. (206 aa)    
Predicted Functional Partners:
cca
Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
  
  
 0.764
ADO50393.1
PFAM: protein of unknown function DUF416; KEGG: kva:Kvar_4861 protein of unknown function DUF416.
  
     0.676
ADO47442.1
Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...]
  
  
 0.666
glnE
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
 
    0.629
ADO50466.1
HemY protein; KEGG: sbc:SbBS512_E4261 putative protoheme IX biogenesis protein; TIGRFAM: HemY protein; PFAM: HemY domain protein.
  
     0.629
ADO46874.1
KEGG: cko:CKO_04501 hypothetical protein.
  
     0.620
ADO50465.1
KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX.
  
     0.571
hldE
rfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
 
    0.566
ftsL
Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
  
     0.545
ADO46980.1
PFAM: adenylate cyclase; KEGG: kpu:KP1_4744 hypothetical protein.
       0.543
Your Current Organism:
Enterobacter lignolyticus
NCBI taxonomy Id: 701347
Other names: Enterobacter lignolyticus SCF1, [. lignolyticus SCF1, [Enterobacter] lignolyticus SCF1
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