Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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mutHDNA mismatch repair endonuclease mutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. (231 aa)    
Predicted Functional Partners:
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 
 0.968
seqA
SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
   
 0.853
ADO47168.1
PFAM: Integral membrane protein TerC; KEGG: kpu:KP1_4513 putative integral membrane transport protein.
     
 0.825
ADO46625.1
KEGG: sek:SSPA3125 DNA adenine methylase; TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase.
 
   
 0.823
metJ
Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.
  
     0.757
proQ
Fertility inhibition FinO-like protein; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family.
  
     0.749
rraB
Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.749
fadR
Fatty acid metabolism transcriptional regulator FadR; Multifunctional regulator of fatty acid metabolism.
  
     0.748
ADO47695.1
PFAM: protein of unknown function DUF412; KEGG: set:SEN2318 hypothetical protein.
  
     0.747
ADO47777.1
PFAM: protein of unknown function DUF1414; KEGG: enc:ECL_03508 hypothetical protein; Belongs to the UPF0352 family.
  
     0.746
Your Current Organism:
Enterobacter lignolyticus
NCBI taxonomy Id: 701347
Other names: Enterobacter lignolyticus SCF1, [. lignolyticus SCF1, [Enterobacter] lignolyticus SCF1
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