STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADO47443.1KEGG: enc:ECL_03909 sigma-E factor negative regulatory protein RseB; manually curated; PFAM: MucB/RseB family protein. (317 aa)    
Predicted Functional Partners:
ADO47442.1
Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...]
 
     0.938
ADO47444.1
PFAM: Positive regulator of sigma(E) RseC/MucC; KEGG: kva:Kvar_1168 positive regulator of sigma E, RseC/MucC.
 
     0.855
ADO47441.1
RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: cko:CKO_00209 RNA polymerase sigma factor RpoE; TIGRFAM: RNA polymerase sigma factor RpoE; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily.
 
     0.830
ADO49769.1
PFAM: Methyltransferase type 11; KEGG: kva:Kvar_4159 methyltransferase type 11.
  
     0.747
seqA
SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.721
lptC
Protein of unknown function DUF1239; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.716
lapA
Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.668
ADO50458.1
PFAM: protein of unknown function DUF484; KEGG: sea:SeAg_B4176 hypothetical protein.
  
     0.650
ADO47777.1
PFAM: protein of unknown function DUF1414; KEGG: enc:ECL_03508 hypothetical protein; Belongs to the UPF0352 family.
  
     0.643
ADO50465.1
KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX.
  
     0.636
Your Current Organism:
Enterobacter lignolyticus
NCBI taxonomy Id: 701347
Other names: Enterobacter lignolyticus SCF1, [. lignolyticus SCF1, [Enterobacter] lignolyticus SCF1
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