| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADO46976.1 | ADO47671.1 | Entcl_0701 | Entcl_1410 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.730 |
| ADO46976.1 | ADO48492.1 | Entcl_0701 | Entcl_2239 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: efe:EFER_1431 short chain dehydrogenase. | 0.901 |
| ADO46976.1 | ADO49916.1 | Entcl_0701 | Entcl_3675 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.577 |
| ADO47347.1 | ADO47671.1 | Entcl_1076 | Entcl_1410 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 thymidylate synthase. | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.841 |
| ADO47347.1 | ADO48492.1 | Entcl_1076 | Entcl_2239 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 thymidylate synthase. | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: efe:EFER_1431 short chain dehydrogenase. | 0.917 |
| ADO47347.1 | ADO49916.1 | Entcl_1076 | Entcl_3675 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 thymidylate synthase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.992 |
| ADO47347.1 | gcvT | Entcl_1076 | Entcl_0847 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 thymidylate synthase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.914 |
| ADO47347.1 | glyA | Entcl_1076 | Entcl_1200 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 thymidylate synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
| ADO47347.1 | thyA | Entcl_1076 | Entcl_0903 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 thymidylate synthase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.928 |
| ADO47671.1 | ADO46976.1 | Entcl_1410 | Entcl_0701 | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.730 |
| ADO47671.1 | ADO47347.1 | Entcl_1410 | Entcl_1076 | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 thymidylate synthase. | 0.841 |
| ADO47671.1 | ADO48492.1 | Entcl_1410 | Entcl_2239 | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: efe:EFER_1431 short chain dehydrogenase. | 0.902 |
| ADO47671.1 | ADO49916.1 | Entcl_1410 | Entcl_3675 | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.953 |
| ADO47671.1 | glyA | Entcl_1410 | Entcl_1200 | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.686 |
| ADO47671.1 | thyA | Entcl_1410 | Entcl_0903 | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.841 |
| ADO48492.1 | ADO46976.1 | Entcl_2239 | Entcl_0701 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: efe:EFER_1431 short chain dehydrogenase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.901 |
| ADO48492.1 | ADO47347.1 | Entcl_2239 | Entcl_1076 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: efe:EFER_1431 short chain dehydrogenase. | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 thymidylate synthase. | 0.917 |
| ADO48492.1 | ADO47671.1 | Entcl_2239 | Entcl_1410 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: efe:EFER_1431 short chain dehydrogenase. | FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.902 |
| ADO48492.1 | ADO49916.1 | Entcl_2239 | Entcl_3675 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: efe:EFER_1431 short chain dehydrogenase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.933 |
| ADO48492.1 | ADO50380.1 | Entcl_2239 | Entcl_4147 | PFAM: short-chain dehydrogenase/reductase SDR; KEGG: efe:EFER_1431 short chain dehydrogenase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.903 |
