Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobBPFAM: Silent information regulator protein Sir2; KEGG: kva:Kvar_3263 silent information regulator protein Sir2; Belongs to the sirtuin family. Class III subfamily. (294 aa)    
Predicted Functional Partners:
ADO49984.1
Transcriptional regulator, XRE family; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain protein; PFAM: helix-turn-helix domain protein; KEGG: cro:ROD_49131 transcriptional regulator; SMART: helix-turn-helix domain protein.
  
 
  0.995
nadD
Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.932
deoD
KEGG: enc:ECL_00796 purine nucleoside phosphorylase; TIGRFAM: purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1.
    
 0.924
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.
    
 0.922
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.918
ADO50024.1
Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.913
sthA
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
   
 0.908
ADO48862.1
Nicotinamidase; KEGG: cro:ROD_12901 pyrazinamidase/nicotinamidase; PFAM: isochorismatase hydrolase.
   
 0.907
nudC
NAD(+) diphosphatase; KEGG: ssn:SSON_4169 NADH pyrophosphatase; PFAM: NUDIX hydrolase; NADH pyrophosphatase-like; Zinc ribbon NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily.
   
  0.907
ADO48495.1
NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family.
     
 0.905
Your Current Organism:
Enterobacter lignolyticus
NCBI taxonomy Id: 701347
Other names: Enterobacter lignolyticus SCF1, [. lignolyticus SCF1, [Enterobacter] lignolyticus SCF1
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