| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADO46992.1 | ADO49496.1 | Entcl_0717 | Entcl_3250 | KEGG: kpu:KP1_4730 outer membrane channel protein; TIGRFAM: type I secretion outer membrane protein, TolC family; PFAM: outer membrane efflux protein. | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.533 |
| ADO46992.1 | macB | Entcl_0717 | Entcl_2911 | KEGG: kpu:KP1_4730 outer membrane channel protein; TIGRFAM: type I secretion outer membrane protein, TolC family; PFAM: outer membrane efflux protein. | ABC transporter related protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.852 |
| ADO47417.1 | ADO49496.1 | Entcl_1150 | Entcl_3250 | KEGG: ent:Ent638_3082 hypothetical protein. | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.524 |
| ADO47417.1 | ADO49497.1 | Entcl_1150 | Entcl_3251 | KEGG: ent:Ent638_3082 hypothetical protein. | KEGG: enc:ECL_01961 Cu(I)/Ag(I) efflux system periplasmic protein CusF. | 0.689 |
| ADO47417.1 | ADO49500.1 | Entcl_1150 | Entcl_3254 | KEGG: ent:Ent638_3082 hypothetical protein. | Heavy metal sensor signal transduction histidine kinase; Member of a two-component regulatory system. | 0.434 |
| ADO48687.1 | ADO49496.1 | Entcl_2436 | Entcl_3250 | KEGG: ent:Ent638_2136 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein. | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.585 |
| ADO48687.1 | ADO49499.1 | Entcl_2436 | Entcl_3253 | KEGG: ent:Ent638_2136 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein. | Two component heavy metal response transcriptional regulator, winged helix family; TIGRFAM: heavy metal response regulator; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; KEGG: cko:CKO_02615 DNA-binding transcriptional activator CusR; SMART: response regulator receiver. | 0.452 |
| ADO48687.1 | macB | Entcl_2436 | Entcl_2911 | KEGG: ent:Ent638_2136 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein. | ABC transporter related protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.504 |
| ADO49495.1 | ADO49496.1 | Entcl_3249 | Entcl_3250 | KEGG: ecl:EcolC_3422 CzcA family heavy metal efflux protein; TIGRFAM: heavy metal efflux pump, CzcA family; PFAM: acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.998 |
| ADO49495.1 | ADO49497.1 | Entcl_3249 | Entcl_3251 | KEGG: ecl:EcolC_3422 CzcA family heavy metal efflux protein; TIGRFAM: heavy metal efflux pump, CzcA family; PFAM: acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | KEGG: enc:ECL_01961 Cu(I)/Ag(I) efflux system periplasmic protein CusF. | 0.941 |
| ADO49495.1 | ADO49498.1 | Entcl_3249 | Entcl_3252 | KEGG: ecl:EcolC_3422 CzcA family heavy metal efflux protein; TIGRFAM: heavy metal efflux pump, CzcA family; PFAM: acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | KEGG: kpn:KPN_pKPN3p05949 copper/silver efflux system outer membrane protein CusC; TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein. | 0.839 |
| ADO49495.1 | ADO49499.1 | Entcl_3249 | Entcl_3253 | KEGG: ecl:EcolC_3422 CzcA family heavy metal efflux protein; TIGRFAM: heavy metal efflux pump, CzcA family; PFAM: acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Two component heavy metal response transcriptional regulator, winged helix family; TIGRFAM: heavy metal response regulator; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; KEGG: cko:CKO_02615 DNA-binding transcriptional activator CusR; SMART: response regulator receiver. | 0.520 |
| ADO49495.1 | ADO49500.1 | Entcl_3249 | Entcl_3254 | KEGG: ecl:EcolC_3422 CzcA family heavy metal efflux protein; TIGRFAM: heavy metal efflux pump, CzcA family; PFAM: acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Heavy metal sensor signal transduction histidine kinase; Member of a two-component regulatory system. | 0.659 |
| ADO49495.1 | ADO49755.1 | Entcl_3249 | Entcl_3511 | KEGG: ecl:EcolC_3422 CzcA family heavy metal efflux protein; TIGRFAM: heavy metal efflux pump, CzcA family; PFAM: acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | KEGG: shm:Shewmr7_2820 RND efflux system outer membrane lipoprotein; TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein. | 0.528 |
| ADO49496.1 | ADO46992.1 | Entcl_3250 | Entcl_0717 | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | KEGG: kpu:KP1_4730 outer membrane channel protein; TIGRFAM: type I secretion outer membrane protein, TolC family; PFAM: outer membrane efflux protein. | 0.533 |
| ADO49496.1 | ADO47417.1 | Entcl_3250 | Entcl_1150 | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | KEGG: ent:Ent638_3082 hypothetical protein. | 0.524 |
| ADO49496.1 | ADO48687.1 | Entcl_3250 | Entcl_2436 | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | KEGG: ent:Ent638_2136 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein. | 0.585 |
| ADO49496.1 | ADO49495.1 | Entcl_3250 | Entcl_3249 | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | KEGG: ecl:EcolC_3422 CzcA family heavy metal efflux protein; TIGRFAM: heavy metal efflux pump, CzcA family; PFAM: acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.998 |
| ADO49496.1 | ADO49497.1 | Entcl_3250 | Entcl_3251 | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | KEGG: enc:ECL_01961 Cu(I)/Ag(I) efflux system periplasmic protein CusF. | 0.974 |
| ADO49496.1 | ADO49498.1 | Entcl_3250 | Entcl_3252 | TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: kpn:KPN_pKPN3p05947 copper/silver efflux system membrane fusion protein CusB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | KEGG: kpn:KPN_pKPN3p05949 copper/silver efflux system outer membrane protein CusC; TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein. | 0.943 |