| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADO47766.1 | ADO49633.1 | Entcl_1505 | Entcl_3388 | PFAM: 2OG-Fe(II) oxygenase; KEGG: kpe:KPK_1519 alkylated DNA repair protein AlkB. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.683 |
| ADO48572.1 | ADO49633.1 | Entcl_2320 | Entcl_3388 | PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: cko:CKO_01575 hypothetical protein. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.476 |
| ADO49632.1 | ADO49633.1 | Entcl_3387 | Entcl_3388 | PFAM: protein of unknown function DUF520; KEGG: cko:CKO_02735 putative nucleotide-binding protein; Belongs to the UPF0234 family. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.644 |
| ADO49632.1 | ADO49634.1 | Entcl_3387 | Entcl_3389 | PFAM: protein of unknown function DUF520; KEGG: cko:CKO_02735 putative nucleotide-binding protein; Belongs to the UPF0234 family. | DJ-1 family protein; KEGG: enc:ECL_01181 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme; TIGRFAM: DJ-1 family protein; PFAM: ThiJ/PfpI domain-containing protein. | 0.547 |
| ADO49633.1 | ADO47766.1 | Entcl_3388 | Entcl_1505 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | PFAM: 2OG-Fe(II) oxygenase; KEGG: kpe:KPK_1519 alkylated DNA repair protein AlkB. | 0.683 |
| ADO49633.1 | ADO48572.1 | Entcl_3388 | Entcl_2320 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: cko:CKO_01575 hypothetical protein. | 0.476 |
| ADO49633.1 | ADO49632.1 | Entcl_3388 | Entcl_3387 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | PFAM: protein of unknown function DUF520; KEGG: cko:CKO_02735 putative nucleotide-binding protein; Belongs to the UPF0234 family. | 0.644 |
| ADO49633.1 | ADO49634.1 | Entcl_3388 | Entcl_3389 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | DJ-1 family protein; KEGG: enc:ECL_01181 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme; TIGRFAM: DJ-1 family protein; PFAM: ThiJ/PfpI domain-containing protein. | 0.835 |
| ADO49633.1 | birA | Entcl_3388 | Entcl_4186 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.598 |
| ADO49633.1 | dgoD | Entcl_3388 | Entcl_0009 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Mandelate racemase/muconate lactonizing protein; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate. | 0.476 |
| ADO49633.1 | panB | Entcl_3388 | Entcl_3593 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.954 |
| ADO49633.1 | panC | Entcl_3388 | Entcl_3594 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.947 |
| ADO49633.1 | panD | Entcl_3388 | Entcl_3595 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.460 |
| ADO49633.1 | queF | Entcl_3388 | Entcl_0925 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.484 |
| ADO49634.1 | ADO49632.1 | Entcl_3389 | Entcl_3387 | DJ-1 family protein; KEGG: enc:ECL_01181 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme; TIGRFAM: DJ-1 family protein; PFAM: ThiJ/PfpI domain-containing protein. | PFAM: protein of unknown function DUF520; KEGG: cko:CKO_02735 putative nucleotide-binding protein; Belongs to the UPF0234 family. | 0.547 |
| ADO49634.1 | ADO49633.1 | Entcl_3389 | Entcl_3388 | DJ-1 family protein; KEGG: enc:ECL_01181 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme; TIGRFAM: DJ-1 family protein; PFAM: ThiJ/PfpI domain-containing protein. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.835 |
| birA | ADO49633.1 | Entcl_4186 | Entcl_3388 | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.598 |
| birA | panB | Entcl_4186 | Entcl_3593 | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.769 |
| birA | panC | Entcl_4186 | Entcl_3594 | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.738 |
| birA | panD | Entcl_4186 | Entcl_3595 | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.723 |