| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADO48612.1 | ADO49772.1 | Entcl_2360 | Entcl_3530 | PFAM: flavin reductase domain protein FMN-binding; KEGG: cro:ROD_15751 flavin reductase-like protein. | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | 0.457 |
| ADO48858.1 | ADO49772.1 | Entcl_2608 | Entcl_3530 | Acid phosphatase; PFAM: phosphoesterase PA-phosphatase related; KEGG: kpu:KP1_2232 acid phosphatase; SMART: phosphoesterase PA-phosphatase related. | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | 0.406 |
| ADO49643.1 | ADO49772.1 | Entcl_3398 | Entcl_3530 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | 0.406 |
| ADO49643.1 | bioB | Entcl_3398 | Entcl_3050 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.439 |
| ADO49643.1 | birA | Entcl_3398 | Entcl_4186 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.655 |
| ADO49772.1 | ADO48612.1 | Entcl_3530 | Entcl_2360 | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | PFAM: flavin reductase domain protein FMN-binding; KEGG: cro:ROD_15751 flavin reductase-like protein. | 0.457 |
| ADO49772.1 | ADO48858.1 | Entcl_3530 | Entcl_2608 | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | Acid phosphatase; PFAM: phosphoesterase PA-phosphatase related; KEGG: kpu:KP1_2232 acid phosphatase; SMART: phosphoesterase PA-phosphatase related. | 0.406 |
| ADO49772.1 | ADO49643.1 | Entcl_3530 | Entcl_3398 | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.406 |
| ADO49772.1 | ADO49773.1 | Entcl_3530 | Entcl_3531 | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: ent:Ent638_0743 hypothetical protein. | 0.580 |
| ADO49772.1 | ADO50435.1 | Entcl_3530 | Entcl_4202 | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | PFAM: Sterol-binding domain protein; KEGG: kpu:KP1_0193 hypothetical protein. | 0.425 |
| ADO49772.1 | bioB | Entcl_3530 | Entcl_3050 | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.510 |
| ADO49772.1 | birA | Entcl_3530 | Entcl_4186 | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.500 |
| ADO49773.1 | ADO49772.1 | Entcl_3531 | Entcl_3530 | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: ent:Ent638_0743 hypothetical protein. | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | 0.580 |
| ADO50435.1 | ADO49772.1 | Entcl_4202 | Entcl_3530 | PFAM: Sterol-binding domain protein; KEGG: kpu:KP1_0193 hypothetical protein. | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | 0.425 |
| bioB | ADO49643.1 | Entcl_3050 | Entcl_3398 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.439 |
| bioB | ADO49772.1 | Entcl_3050 | Entcl_3530 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | 0.510 |
| bioB | birA | Entcl_3050 | Entcl_4186 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.959 |
| birA | ADO49643.1 | Entcl_4186 | Entcl_3398 | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.655 |
| birA | ADO49772.1 | Entcl_4186 | Entcl_3530 | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Methyltransferase type 11; KEGG: kpe:KPK_4509 methyltransferase, UbiE/COQ5 family; manually curated; PFAM: Methyltransferase type 11. | 0.500 |
| birA | bioB | Entcl_4186 | Entcl_3050 | Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.959 |