Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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lexATranscriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa)    
Predicted Functional Partners:
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.953
dinB
DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.759
ADO50357.1
MATE efflux family protein; KEGG: kpu:KP1_0284 DNA-damage-inducible SOS response protein; TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE.
  
  
 0.757
ADO47373.1
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.726
ADO48141.1
KEGG: eoj:ECO26_1697 DNA polymerase V subunit UmuC; PFAM: UMUC domain protein DNA-repair protein; Belongs to the DNA polymerase type-Y family.
 
 
 0.693
ADO48372.1
KEGG: kpe:KPK_3125 DNA polymerase V subunit UmuC; PFAM: UMUC domain protein DNA-repair protein.
 
 
 0.692
atpA
ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
      
 0.650
sulA
Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
  
  
 0.604
ADO50359.1
Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid.
       0.549
plsB
Glycerol-3-phosphate O-acyltransferase; PFAM: phospholipid/glycerol acyltransferase; KEGG: sbo:SBO_4076 glycerol-3-phosphate acyltransferase; SMART: phospholipid/glycerol acyltransferase; Belongs to the GPAT/DAPAT family.
     
 0.498
Your Current Organism:
Enterobacter lignolyticus
NCBI taxonomy Id: 701347
Other names: Enterobacter lignolyticus SCF1, [. lignolyticus SCF1, [Enterobacter] lignolyticus SCF1
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