| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADO47993.1 | ADO48030.1 | Entcl_1736 | Entcl_1773 | TIGRFAM: uroporphyrin-III C-methyltransferase; KEGG: xbo:XBJ1_0853 uroporphyrin-III C-methyltransferase (urogen III methylase) (SumT) (uroporphyrinogen III methylase) (UroM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | KEGG: sea:SeAg_B2146 cobalt-precorrin-2 C(20)-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.937 |
| ADO47993.1 | ADO50464.1 | Entcl_1736 | Entcl_4231 | TIGRFAM: uroporphyrin-III C-methyltransferase; KEGG: xbo:XBJ1_0853 uroporphyrin-III C-methyltransferase (urogen III methylase) (SumT) (uroporphyrinogen III methylase) (UroM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.916 |
| ADO47993.1 | ADO50465.1 | Entcl_1736 | Entcl_4232 | TIGRFAM: uroporphyrin-III C-methyltransferase; KEGG: xbo:XBJ1_0853 uroporphyrin-III C-methyltransferase (urogen III methylase) (SumT) (uroporphyrinogen III methylase) (UroM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX. | 0.900 |
| ADO47993.1 | cysG | Entcl_1736 | Entcl_0359 | TIGRFAM: uroporphyrin-III C-methyltransferase; KEGG: xbo:XBJ1_0853 uroporphyrin-III C-methyltransferase (urogen III methylase) (SumT) (uroporphyrinogen III methylase) (UroM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.944 |
| ADO47993.1 | cysG-2 | Entcl_1736 | Entcl_0947 | TIGRFAM: uroporphyrin-III C-methyltransferase; KEGG: xbo:XBJ1_0853 uroporphyrin-III C-methyltransferase (urogen III methylase) (SumT) (uroporphyrinogen III methylase) (UroM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.944 |
| ADO47993.1 | hemC | Entcl_1736 | Entcl_4230 | TIGRFAM: uroporphyrin-III C-methyltransferase; KEGG: xbo:XBJ1_0853 uroporphyrin-III C-methyltransferase (urogen III methylase) (SumT) (uroporphyrinogen III methylase) (UroM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.983 |
| ADO47993.1 | hemE | Entcl_1736 | Entcl_4162 | TIGRFAM: uroporphyrin-III C-methyltransferase; KEGG: xbo:XBJ1_0853 uroporphyrin-III C-methyltransferase (urogen III methylase) (SumT) (uroporphyrinogen III methylase) (UroM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.913 |
| ADO48030.1 | ADO47993.1 | Entcl_1773 | Entcl_1736 | KEGG: sea:SeAg_B2146 cobalt-precorrin-2 C(20)-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: uroporphyrin-III C-methyltransferase; KEGG: xbo:XBJ1_0853 uroporphyrin-III C-methyltransferase (urogen III methylase) (SumT) (uroporphyrinogen III methylase) (UroM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.937 |
| ADO48030.1 | ADO50465.1 | Entcl_1773 | Entcl_4232 | KEGG: sea:SeAg_B2146 cobalt-precorrin-2 C(20)-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX. | 0.900 |
| ADO48030.1 | cysG | Entcl_1773 | Entcl_0359 | KEGG: sea:SeAg_B2146 cobalt-precorrin-2 C(20)-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.957 |
| ADO48030.1 | cysG-2 | Entcl_1773 | Entcl_0947 | KEGG: sea:SeAg_B2146 cobalt-precorrin-2 C(20)-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.956 |
| ADO50462.1 | ADO50464.1 | Entcl_4229 | Entcl_4231 | KEGG: enc:ECL_04985 adenylate cyclase; PFAM: adenylate cyclase class-I; Belongs to the adenylyl cyclase class-1 family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.584 |
| ADO50462.1 | ADO50465.1 | Entcl_4229 | Entcl_4232 | KEGG: enc:ECL_04985 adenylate cyclase; PFAM: adenylate cyclase class-I; Belongs to the adenylyl cyclase class-1 family. | KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX. | 0.782 |
| ADO50462.1 | ADO50466.1 | Entcl_4229 | Entcl_4233 | KEGG: enc:ECL_04985 adenylate cyclase; PFAM: adenylate cyclase class-I; Belongs to the adenylyl cyclase class-1 family. | HemY protein; KEGG: sbc:SbBS512_E4261 putative protoheme IX biogenesis protein; TIGRFAM: HemY protein; PFAM: HemY domain protein. | 0.801 |
| ADO50462.1 | hemC | Entcl_4229 | Entcl_4230 | KEGG: enc:ECL_04985 adenylate cyclase; PFAM: adenylate cyclase class-I; Belongs to the adenylyl cyclase class-1 family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.519 |
| ADO50464.1 | ADO47993.1 | Entcl_4231 | Entcl_1736 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: uroporphyrin-III C-methyltransferase; KEGG: xbo:XBJ1_0853 uroporphyrin-III C-methyltransferase (urogen III methylase) (SumT) (uroporphyrinogen III methylase) (UroM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. | 0.916 |
| ADO50464.1 | ADO50462.1 | Entcl_4231 | Entcl_4229 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | KEGG: enc:ECL_04985 adenylate cyclase; PFAM: adenylate cyclase class-I; Belongs to the adenylyl cyclase class-1 family. | 0.584 |
| ADO50464.1 | ADO50465.1 | Entcl_4231 | Entcl_4232 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | KEGG: cko:CKO_00145 putative uroporphyrinogen III C-methyltransferase; PFAM: protein of unknown function DUF513 hemX. | 0.988 |
| ADO50464.1 | ADO50466.1 | Entcl_4231 | Entcl_4233 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | HemY protein; KEGG: sbc:SbBS512_E4261 putative protoheme IX biogenesis protein; TIGRFAM: HemY protein; PFAM: HemY domain protein. | 0.868 |
| ADO50464.1 | cysG | Entcl_4231 | Entcl_0359 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.964 |