| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUW_1324 | apt | CUW_1324 | CUW_1603 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.720 |
| CUW_1324 | argS | CUW_1324 | CUW_1797 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | arginine--tRNA ligase; Identified by match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM PF09334; match to protein family HMM TIGR00456. | 0.651 |
| CUW_1324 | gmk | CUW_1324 | CUW_1098 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.667 |
| CUW_1324 | guaA | CUW_1324 | CUW_1663 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | GMP synthase (glutamine-hydrolyzing), C-terminal domain protein; Catalyzes the synthesis of GMP from XMP. | 0.998 |
| CUW_1324 | guaB | CUW_1324 | CUW_1319 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.864 |
| CUW_1324 | hpt | CUW_1324 | CUW_2525 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.400 |
| CUW_1324 | pyrG | CUW_1324 | CUW_2677 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.544 |
| CUW_1324 | xpt | CUW_1324 | CUW_1379 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.720 |
| apt | CUW_1324 | CUW_1603 | CUW_1324 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | 0.720 |
| apt | gmk | CUW_1603 | CUW_1098 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.956 |
| apt | guaA | CUW_1603 | CUW_1663 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing), C-terminal domain protein; Catalyzes the synthesis of GMP from XMP. | 0.979 |
| apt | guaB | CUW_1603 | CUW_1319 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.504 |
| apt | hpt | CUW_1603 | CUW_2525 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.935 |
| apt | pyrG | CUW_1603 | CUW_2677 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.477 |
| apt | xpt | CUW_1603 | CUW_1379 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.918 |
| argS | CUW_1324 | CUW_1797 | CUW_1324 | arginine--tRNA ligase; Identified by match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM PF09334; match to protein family HMM TIGR00456. | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | 0.651 |
| argS | gmk | CUW_1797 | CUW_1098 | arginine--tRNA ligase; Identified by match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM PF09334; match to protein family HMM TIGR00456. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.448 |
| argS | guaA | CUW_1797 | CUW_1663 | arginine--tRNA ligase; Identified by match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM PF09334; match to protein family HMM TIGR00456. | GMP synthase (glutamine-hydrolyzing), C-terminal domain protein; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| argS | guaB | CUW_1797 | CUW_1319 | arginine--tRNA ligase; Identified by match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM PF09334; match to protein family HMM TIGR00456. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.486 |
| argS | pyrG | CUW_1797 | CUW_2677 | arginine--tRNA ligase; Identified by match to protein family HMM PF00750; match to protein family HMM PF01406; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM PF09334; match to protein family HMM TIGR00456. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.715 |