| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| F897_00083 | F897_02607 | F897_00083 | F897_02607 | Acetolactate synthase. | Chorismate mutase. | 0.587 |
| F897_00083 | ilvA | F897_00083 | F897_01944 | Acetolactate synthase. | L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.975 |
| F897_00083 | ilvN | F897_00083 | F897_00082 | Acetolactate synthase. | Acetolactate synthase, small subunit. | 0.999 |
| F897_00083 | rutC | F897_00083 | F897_01626 | Acetolactate synthase. | Putative aminoacrylate peracid reductase RutC; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation. | 0.490 |
| F897_01627 | F897_01628 | F897_01627 | F897_01628 | NAD(P)H-flavin reductase RutF; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | Pyrimidine utilization transporter G. | 0.668 |
| F897_01627 | rutA | F897_01627 | F897_01624 | NAD(P)H-flavin reductase RutF; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | Pyrimidine monooxygenase RutA; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. | 0.983 |
| F897_01627 | rutB | F897_01627 | F897_01625 | NAD(P)H-flavin reductase RutF; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. | 0.983 |
| F897_01627 | rutC | F897_01627 | F897_01626 | NAD(P)H-flavin reductase RutF; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | Putative aminoacrylate peracid reductase RutC; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation. | 0.815 |
| F897_01627 | rutD | F897_01627 | F897_01623 | NAD(P)H-flavin reductase RutF; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | Putative aminoacrylate hydrolase RutD; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family. | 0.546 |
| F897_01628 | F897_01627 | F897_01628 | F897_01627 | Pyrimidine utilization transporter G. | NAD(P)H-flavin reductase RutF; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | 0.668 |
| F897_01628 | rutA | F897_01628 | F897_01624 | Pyrimidine utilization transporter G. | Pyrimidine monooxygenase RutA; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. | 0.486 |
| F897_01628 | rutB | F897_01628 | F897_01625 | Pyrimidine utilization transporter G. | Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. | 0.490 |
| F897_01628 | rutC | F897_01628 | F897_01626 | Pyrimidine utilization transporter G. | Putative aminoacrylate peracid reductase RutC; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation. | 0.547 |
| F897_02607 | F897_00083 | F897_02607 | F897_00083 | Chorismate mutase. | Acetolactate synthase. | 0.587 |
| F897_02607 | ilvA | F897_02607 | F897_01944 | Chorismate mutase. | L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.540 |
| F897_02607 | ilvN | F897_02607 | F897_00082 | Chorismate mutase. | Acetolactate synthase, small subunit. | 0.682 |
| F897_02607 | rutC | F897_02607 | F897_01626 | Chorismate mutase. | Putative aminoacrylate peracid reductase RutC; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation. | 0.527 |
| F897_02607 | rutD | F897_02607 | F897_01623 | Chorismate mutase. | Putative aminoacrylate hydrolase RutD; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family. | 0.445 |
| fusA | rutC | F897_01267 | F897_01626 | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | Putative aminoacrylate peracid reductase RutC; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation. | 0.681 |
| ilvA | F897_00083 | F897_01944 | F897_00083 | L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase. | 0.975 |
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