A0A090MDA5 protein (Ostreococcus tauri) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A090MDA5

Uncharacterized protein. (196 aa)

Predicted Functional Partners:

A0A096P9F8

0.769

A0A090M748

0.614

A0A090M4T2

0.600

A0A090M8W0

0.600

Q00Y35_OSTTA

0.547

A0A096P8T7

0.484

Q015H4_OSTTA

0.465

A0A090M2V3

0.452

A0A090MAA5

0.452

A0A090MCP0

0.452

Your Current Organism:

Ostreococcus tauri

NCBI taxonomy Id: 70448
Other names: O. tauri

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A090M2V3	A0A090M4T2	A0A090M2V3	A0A090M4T2	Superoxide dismutase, Nickel-type.	Cullin repeat-like-containing domain; Belongs to the cullin family.	0.571
A0A090M2V3	A0A090M748	A0A090M2V3	A0A090M748	Superoxide dismutase, Nickel-type.	Zinc finger, RING-H2-type.	0.587
A0A090M2V3	A0A090M8W0	A0A090M2V3	A0A090M8W0	Superoxide dismutase, Nickel-type.	Cullin repeat-like-containing domain; Belongs to the cullin family.	0.571
A0A090M2V3	A0A090MDA5	A0A090M2V3	A0A090MDA5	Superoxide dismutase, Nickel-type.	Uncharacterized protein.	0.452
A0A090M2V3	A0A096P8T7	A0A090M2V3	A0A096P8T7	Superoxide dismutase, Nickel-type.	Ubiquitin supergroup.	0.501
A0A090M2V3	A0A096P9F8	A0A090M2V3	A0A096P9F8	Superoxide dismutase, Nickel-type.	E3 ubiquitin ligase, SCF complex, Skp subunit; Belongs to the SKP1 family.	0.746
A0A090M2V3	Q00Y35_OSTTA	A0A090M2V3	Q00Y35	Superoxide dismutase, Nickel-type.	SKP1 component, POZ domain; Belongs to the SKP1 family.	0.528
A0A090M4T2	A0A090M2V3	A0A090M4T2	A0A090M2V3	Cullin repeat-like-containing domain; Belongs to the cullin family.	Superoxide dismutase, Nickel-type.	0.571
A0A090M4T2	A0A090M748	A0A090M4T2	A0A090M748	Cullin repeat-like-containing domain; Belongs to the cullin family.	Zinc finger, RING-H2-type.	0.937
A0A090M4T2	A0A090MAA5	A0A090M4T2	A0A090MAA5	Cullin repeat-like-containing domain; Belongs to the cullin family.	Sde2 N-terminal domain.	0.573
A0A090M4T2	A0A090MCP0	A0A090M4T2	A0A090MCP0	Cullin repeat-like-containing domain; Belongs to the cullin family.	Ubiquitin conserved site.	0.571
A0A090M4T2	A0A090MDA5	A0A090M4T2	A0A090MDA5	Cullin repeat-like-containing domain; Belongs to the cullin family.	Uncharacterized protein.	0.600
A0A090M4T2	A0A096P8T7	A0A090M4T2	A0A096P8T7	Cullin repeat-like-containing domain; Belongs to the cullin family.	Ubiquitin supergroup.	0.935
A0A090M4T2	A0A096P9F8	A0A090M4T2	A0A096P9F8	Cullin repeat-like-containing domain; Belongs to the cullin family.	E3 ubiquitin ligase, SCF complex, Skp subunit; Belongs to the SKP1 family.	0.937
A0A090M4T2	Q00Y35_OSTTA	A0A090M4T2	Q00Y35	Cullin repeat-like-containing domain; Belongs to the cullin family.	SKP1 component, POZ domain; Belongs to the SKP1 family.	0.708
A0A090M4T2	Q015H4_OSTTA	A0A090M4T2	Q015H4	Cullin repeat-like-containing domain; Belongs to the cullin family.	Ubiquitin supergroup.	0.573
A0A090M748	A0A090M2V3	A0A090M748	A0A090M2V3	Zinc finger, RING-H2-type.	Superoxide dismutase, Nickel-type.	0.587
A0A090M748	A0A090M4T2	A0A090M748	A0A090M4T2	Zinc finger, RING-H2-type.	Cullin repeat-like-containing domain; Belongs to the cullin family.	0.937
A0A090M748	A0A090M8W0	A0A090M748	A0A090M8W0	Zinc finger, RING-H2-type.	Cullin repeat-like-containing domain; Belongs to the cullin family.	0.969
A0A090M748	A0A090MAA5	A0A090M748	A0A090MAA5	Zinc finger, RING-H2-type.	Sde2 N-terminal domain.	0.587

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.715

expected number of edges:

36

PPI enrichment p-value:

0.514

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

6 of 131

1.92

2.98

1.77e-07

GO:0048312

Intracellular distribution of mitochondria

2 of 4

2.96

1.53

0.0017

GO:1902115

Regulation of organelle assembly

3 of 50

2.04

1.48

0.0013

GO:1900242

Regulation of synaptic vesicle endocytosis

2 of 5

2.87

1.48

0.0021

GO:0007154

Cell communication

9 of 1248

1.12

1.33

1.51e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030159

Signaling receptor complex adaptor activity

3 of 22

2.4

1.78

0.00047

GO:0001965

G-protein alpha-subunit binding

2 of 5

2.87

1.38

0.0032

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

4 of 13

2.75

3.74

1.08e-07

GO:0044297

Cell body

2 of 26

2.15

1.18

0.0061

GO:0043195

Terminal bouton

2 of 23

2.2

1.18

0.0061

GO:0071944

Cell periphery

7 of 1721

0.87

0.74

0.00070

GO:0005770

Late endosome

2 of 83

1.65

0.69

0.0426

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10680

GPCR ligand binding, and Regulation of G protein-coupled receptor signaling pathway

7 of 75

2.23

5.07

1.03e-11

CL:10782

RGS domain, and GTPase complex

5 of 20

2.66

4.96

3.29e-10

CL:10783

RGS domain, and GTPase complex

4 of 13

2.75

4.01

3.19e-08

CL:344

Intracellular distribution of mitochondria, and Immunoglobulin V-set domain

2 of 5

2.87

1.57

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-418594

G alpha (i) signalling events

6 of 83

2.12

4.03

1.67e-09

MAP-372790

Signaling by GPCR

7 of 156

1.92

3.73

7.50e-10

MAP-373080

Class B/2 (Secretin family receptors)

3 of 4

3.14

3.25

1.25e-06

MAP-202040

G-protein activation

3 of 4

3.14

3.25

1.25e-06

MAP-397795

G-protein beta:gamma signalling

3 of 7

2.9

3.09

2.14e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098562

Cytoplasmic side of membrane

5 of 27

2.53

4.37

3.37e-09

GOCC:0005834

Heterotrimeric G-protein complex

3 of 11

2.7

2.73

8.88e-06

GOCC:0032473

Cytoplasmic side of mitochondrial outer membrane

2 of 2

3.26

2.12

0.00015

GOCC:0071944

Cell periphery

8 of 696

1.32

1.87

1.07e-07

GOCC:0005886

Plasma membrane

7 of 614

1.32

1.68

1.90e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

3 of 130

1.63

0.96

0.0102

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

3 of 3

3.26

2.84

7.33e-06

IPR001632

G-protein, beta subunit

2 of 2

3.26

1.45

0.0025

IPR019775

WD40 repeat, conserved site

3 of 65

1.93

1.14

0.0060

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

3 of 161

1.53

0.73

0.0327

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