node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A090M2Y4 | A0A096P8L5 | A0A090M2Y4 | A0A096P8L5 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Pseudouridine synthase, RsuA/RluB/C/D/E/F. | 0.778 |
A0A090M2Y4 | Q00TP4_OSTTA | A0A090M2Y4 | Q00TP4 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Pseudouridine synthase, RluC/RluD, conserved site. | 0.778 |
A0A090M2Y4 | Q013L4_OSTTA | A0A090M2Y4 | Q013L4 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.471 |
A0A090M8E4 | A0A096P8L5 | A0A090M8E4 | A0A096P8L5 | Pseudouridine synthase II. | Pseudouridine synthase, RsuA/RluB/C/D/E/F. | 0.518 |
A0A090M8E4 | A0A096PAD0 | A0A090M8E4 | A0A096PAD0 | Pseudouridine synthase II. | tRNA-guanine(15) transglycosylase-like. | 0.441 |
A0A090M8E4 | Q00TP4_OSTTA | A0A090M8E4 | Q00TP4 | Pseudouridine synthase II. | Pseudouridine synthase, RluC/RluD, conserved site. | 0.518 |
A0A090M8E4 | Q011N4_OSTTA | A0A090M8E4 | Q011N4 | Pseudouridine synthase II. | tRNA wybutosine-synthesizing protein. | 0.661 |
A0A090M8E4 | Q013L4_OSTTA | A0A090M8E4 | Q013L4 | Pseudouridine synthase II. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.441 |
A0A090MAW9 | A0A096PAD0 | A0A090MAW9 | A0A096PAD0 | Translation initiation factor 3. | tRNA-guanine(15) transglycosylase-like. | 0.419 |
A0A090MAW9 | Q013L4_OSTTA | A0A090MAW9 | Q013L4 | Translation initiation factor 3. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.419 |
A0A090MBG7 | A0A096P8L5 | A0A090MBG7 | A0A096P8L5 | Pseudouridine synthase/archaeosine transglycosylase. | Pseudouridine synthase, RsuA/RluB/C/D/E/F. | 0.518 |
A0A090MBG7 | A0A096PAD0 | A0A090MBG7 | A0A096PAD0 | Pseudouridine synthase/archaeosine transglycosylase. | tRNA-guanine(15) transglycosylase-like. | 0.441 |
A0A090MBG7 | Q00TP4_OSTTA | A0A090MBG7 | Q00TP4 | Pseudouridine synthase/archaeosine transglycosylase. | Pseudouridine synthase, RluC/RluD, conserved site. | 0.518 |
A0A090MBG7 | Q011N4_OSTTA | A0A090MBG7 | Q011N4 | Pseudouridine synthase/archaeosine transglycosylase. | tRNA wybutosine-synthesizing protein. | 0.661 |
A0A090MBG7 | Q013L4_OSTTA | A0A090MBG7 | Q013L4 | Pseudouridine synthase/archaeosine transglycosylase. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.441 |
A0A096P8L5 | A0A090M2Y4 | A0A096P8L5 | A0A090M2Y4 | Pseudouridine synthase, RsuA/RluB/C/D/E/F. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.778 |
A0A096P8L5 | A0A090M8E4 | A0A096P8L5 | A0A090M8E4 | Pseudouridine synthase, RsuA/RluB/C/D/E/F. | Pseudouridine synthase II. | 0.518 |
A0A096P8L5 | A0A090MBG7 | A0A096P8L5 | A0A090MBG7 | Pseudouridine synthase, RsuA/RluB/C/D/E/F. | Pseudouridine synthase/archaeosine transglycosylase. | 0.518 |
A0A096P8L5 | A0A096PAD0 | A0A096P8L5 | A0A096PAD0 | Pseudouridine synthase, RsuA/RluB/C/D/E/F. | tRNA-guanine(15) transglycosylase-like. | 0.402 |
A0A096P8L5 | Q011N4_OSTTA | A0A096P8L5 | Q011N4 | Pseudouridine synthase, RsuA/RluB/C/D/E/F. | tRNA wybutosine-synthesizing protein. | 0.450 |