node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PH0112 | PH0113 | gene:9377020 | gene:9377021 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.987 |
PH0112 | PH0195 | gene:9377020 | gene:9377105 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 346aa long hypothetical protein; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synth [...] | 0.973 |
PH0112 | PH0196 | gene:9377020 | gene:9377106 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 397aa long hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.866 |
PH0112 | PH0606 | gene:9377020 | gene:9377547 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 1108aa long hypothetical cell division control protein; Similar to Swiss_Prot:P30665 percent identity:41.538 in 331aa. motif=ATP/GTP-binding site motif A (P-loop); protein splicing signature; Belongs to the MCM family. | 0.959 |
PH0112 | PH0665 | gene:9377020 | gene:9377609 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 249aa long hypothetical proliferating-cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.963 |
PH0112 | PH1415 | gene:9377020 | gene:9378391 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 343aa long hypothetical 5' nuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.941 |
PH0112 | PH1622 | gene:9377020 | gene:9378612 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 559aa long hypothetical DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.727 |
PH0112 | PH1650 | gene:9377020 | gene:9378643 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 220aa long hypothetical ribonuclease H II; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.747 |
PH0112 | PH1947 | gene:9377020 | gene:9378960 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 1235aa long hypothetical DNA-directed DNA polymerase; Similar to PIR:S68593 percent identity: 75.831 in 1312aa; Swiss_Prot:P30317 percent identity: 67.133 in 1082aa; owl:PYWKODPOL percent identity: 75.792 in 1671aa. motif=DNA polymerase family B signature; protein splicing signature; Belongs to the DNA polymerase type-B family. | 0.955 |
PH0112 | PHS020 | gene:9377020 | gene:9377402 | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 97aa long hypothetical protein; Similar to PIR:H64330 percent identity:36.047 in 88aa; Swiss_Prot:P18248 percent identity:20.588 in 68aa. | 0.937 |
PH0113 | PH0112 | gene:9377021 | gene:9377020 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.987 |
PH0113 | PH0195 | gene:9377021 | gene:9377105 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 346aa long hypothetical protein; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synth [...] | 0.940 |
PH0113 | PH0196 | gene:9377021 | gene:9377106 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 397aa long hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.935 |
PH0113 | PH0606 | gene:9377021 | gene:9377547 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 1108aa long hypothetical cell division control protein; Similar to Swiss_Prot:P30665 percent identity:41.538 in 331aa. motif=ATP/GTP-binding site motif A (P-loop); protein splicing signature; Belongs to the MCM family. | 0.881 |
PH0113 | PH0665 | gene:9377021 | gene:9377609 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 249aa long hypothetical proliferating-cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.859 |
PH0113 | PH1415 | gene:9377021 | gene:9378391 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 343aa long hypothetical 5' nuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.846 |
PH0113 | PH1622 | gene:9377021 | gene:9378612 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 559aa long hypothetical DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.925 |
PH0113 | PH1650 | gene:9377021 | gene:9378643 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 220aa long hypothetical ribonuclease H II; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.879 |
PH0113 | PH1947 | gene:9377021 | gene:9378960 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 1235aa long hypothetical DNA-directed DNA polymerase; Similar to PIR:S68593 percent identity: 75.831 in 1312aa; Swiss_Prot:P30317 percent identity: 67.133 in 1082aa; owl:PYWKODPOL percent identity: 75.792 in 1671aa. motif=DNA polymerase family B signature; protein splicing signature; Belongs to the DNA polymerase type-B family. | 0.939 |
PH0113 | PHS020 | gene:9377021 | gene:9377402 | 468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 97aa long hypothetical protein; Similar to PIR:H64330 percent identity:36.047 in 88aa; Swiss_Prot:P18248 percent identity:20.588 in 68aa. | 0.839 |