STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PH0999180aa long hypothetical pyrazinamidase/nicotinamidase; Similar to owl:AF0082061 percent identity: 39.884 in 183aa; owl:MTU59967 percent identity: 39.306 in 182aa; Swiss_Prot:P21369 percent identity: 41.954 in 199aa. (180 aa)    
Predicted Functional Partners:
PH1868
392aa long hypothetical protein.
 
 0.997
PH0947
249aa long hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily.
  
 0.935
PH1805
341aa long hypothetical 3-hydroxy-3-methylglutaryl coenzyme A reductase; Converts HMG-CoA to mevalonate.
    
 0.759
PH1202
371aa long hypothetical protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
     
 0.743
PH0642
262aa long hypothetical protein; Similar to owl:PBU4258077 percent identity:40.397 in 157aa; owl:HPAE0005494 percent identity:38.136 in 257aa; Swiss_Prot:P55176 percent identity:32.540 in 265aa. motif=ATP/GTP-binding site motif A (P-loop).
   
 
 0.674
PH0182
257aa long hypothetical NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
  
 0.663
PH0997
374aa long hypothetical protein.
       0.636
PH0011
283aa long hypothetical nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
  
 
 0.600
PH1542
150aa long hypothetical 30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family.
  
  
 0.559
PH0015
464aa long hypothetical L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.534
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.